heart failure

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

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Study Counts

Type	Study_count
Total_Studies	2487
interventional	1779
Observational	606
Registry	102

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Device	344
Drug	332
Drug|placebo	285
Other	241
Behavioral	218
Procedure	88
Device|Other	34
Drug|Other	22
Biological	20
Behavioral|Other	18
Diagnostic Test	18
Dietary Supplement	18
Drug|Procedure	17
Dietary Supplement|placebo	15
Device|Drug	14
Device|Procedure	12
Other|Procedure	9
Biological|placebo	6
Other|placebo	6
Biological|Other	5
Behavioral|Drug	4
Combination Product	4
Dietary Supplement|Other	4
Drug|Other|placebo	4
Behavioral|Device	3
Radiation	3
Behavioral|Procedure	2
Biological|Drug	2
Biological|Procedure	2
Combination Product|Other	2
Device|Diagnostic Test	2
Genetic|placebo	2
Behavioral|Diagnostic Test|Other	1
Behavioral|Dietary Supplement	1
Behavioral|Dietary Supplement|Other	1
Behavioral|placebo	1
Biological|Device	1
Biological|Diagnostic Test	1
Device|Diagnostic Test|Procedure	1
Device|Drug|Other	1
Device|Drug|Other|placebo	1
Device|Drug|Procedure	1
Device|Other|Procedure	1
Device|placebo	1
Device|Radiation	1
Diagnostic Test|Drug	1
Diagnostic Test|Drug|placebo	1
Diagnostic Test|Other	1
Diagnostic Test|Procedure	1
Diagnostic Test|Procedure|Radiation	1
Dietary Supplement|Drug|placebo	1
Drug|Genetic|Other|placebo|Procedure	1
Drug|Other|placebo|Procedure|Radiation	1
Other|Radiation	1
placebo	1

Count of Studies by Intervention (normalized and mapped)

Intervention_type	intervention	Study_count	Date of First Study
placebo	placebo	267	2014
Other	standard care	52	2014
Drug	nesiritide	17	2010
Drug	spironolactone	17	2010
Drug	carvedilol	16	2010
Drug	tolvaptan	16	2016
Drug	valsartan	16	2013
Drug	furosemide	15	2009
Drug	levosimendan	15	2012
Drug	enalapril	14	2017
Behavioral	exercise	14	2010
Drug	ivabradine	14	2017
Drug	lcz696	14	2013
Other	control	13	2016
Device	cardiac resynchronization therapy	12	2018
Drug	sildenafil	11	2010
Other	exercise training	10	2016
Drug	empagliflozin	9	2018
Drug	sacubitril	9	2018
Drug	saline	9	2016
Drug	dapagliflozin	8	2016
Drug	allopurinol	7	2014
Drug	atorvastatin	7	2017
Drug	eplerenone	7	2013
Drug	ferric carboxymaltose	7	2013
Device	icd	7	2010
Drug	metformin	7	2010
Other	telemonitoring	7	2018
Drug	anakinra	6	2010
Other	attention control	6	2010
Device	crt-d	6	2014
Behavioral	education	6	2017
Drug	vitamin d	6	2013
Drug	aliskiren	5	2009
Drug	bisoprolol	5	2018
Drug	bms-986231	5	2016
Drug	candesartan	5	2008
Procedure	cardiac rehabilitation	5	2012
Device	crt	5	2009
Drug	darbepoetin alfa	5	2006
Drug	omecamtiv mecarbil	5	2016
Drug	rosuvastatin	5	2017
Behavioral	telehealth	5	2017
Procedure	ultrafiltration	5	2010
Drug	acetazolamide	4	2011
Drug	bia 5-453	4	2017
Other	blood sample	4	2012
Drug	cd-np	4	2009
Device	cpap	4	2015
Drug	digoxin	4	2015
Drug	dobutamine	4	2011
Other	echocardiography	4	2019
Drug	empagliflozin 10 mg	4	2017
Behavioral	health education	4	2012
Drug	lcz696 (sacubitril	4	2016
Drug	lcz696 (sacubitril/valsartan)	4	2016
Drug	loop diuretics	4	2019
Device	optimal medical therapy	4	2014
Device	pacing lead	4	2009
Drug	prednisone	4	2014
Drug	rolofylline	4	2008
Drug	sacubitril/valsartan	4	2018
Drug	thiamine	4	2010
Drug	valsartan)	4	2016
Drug	ace inhibitor	3	2006
Procedure	acupuncture	3	2020
Other	aerobic	3	2013
Other	aerobic training	3	2016
Drug	amiodarone	3	2008
Other	blood draw	3	2011
Drug	ca125 guided strategy	3	2015
Drug	cenderitide	3	2011
placebo	comparator: placebo (unspecified)	3	2006
Drug	diuretics	3	2010
placebo	enalapril matching placebo	3	2015
Behavioral	high-intensity imt	3	2012
Behavioral	high-intensity interval training	3	2016
Other	inspiratory muscle training	3	2012
Biological	ixmyelocel-t	3	2009
Other	life completion	3	2010
Drug	liothyronine	3	2011
Drug	liraglutide	3	2011
Other	lung ultrasound	3	2016
Drug	lysine chloride	3	2018
Drug	nebivolol	3	2014
Dietary Supplement	nitrate-rich beetroot juice	3	2018
Drug	nitroglycerin	3	2013
Drug	opc-41061(tolvaptan)	3	2007
Drug	oxygen	3	2019
Drug	patiromer	3	2010
Behavioral	physical activity	3	2017
placebo	placebo of enalapril	3	2016
placebo	placebo of lcz696	3	2016
Other	positron emission tomography	3	2015
Drug	ranolazine	3	2011
Other	resistance training	3	2018
Drug	rlx030	3	2013
Other	sham	3	2012
Drug	sitagliptin	3	2016
Drug	123i-mibg (meta-iodobenzylguanidine)	2	2005
Device	a	2	2007
Device	adaptive servo-ventilation	2	2016
Device	adaptive servo ventilation	2	2010
Other	advanced imaging	2	2011
Behavioral	aerobic endurance exercise training (ergometer)	2	2005
Drug	alt-711	2	2007
Drug	amlodipine	2	2011
Drug	angiotensin ii type 1 receptor antagonists	2	1999
Drug	aspirin	2	2012
Drug	azd9977	2	2018
Device	b	2	2007
Device	barostim neo system	2	2011
Device	barostim neoâ® system	2	2015
Drug	bay94-8862	2	2013
Drug	bia 5-1058	2	2018
Behavioral	bluetooth scale	2	2016
Procedure	cabg surgery	2	2015
Device	cardiac resynchronization therapy (crt)	2	2015
Device	cardiac resynchronization therapy defibrillator	2	2017
Device	cardiac resynchronization therapy with defibrillation	2	2006
Diagnostic Test	cardiopulmonary exercise test	2	2013
Device	carillon mitral contour system	2	2017
Drug	cholecalciferol	2	2011
Drug	ck-1827452	2	2009
Behavioral	clinical reminder	2	2012
Drug	clp	2	2012
Behavioral	combined aerobic	2	2018
Drug	conivaptan	2	2012
Device	continuous positive airway pressure (cpap)	2	2017
Device	control lvad	2	2010
Biological	control solution	2	2015
Drug	conventional strategy	2	2016
Drug	cor-1	2	2010
Device	cordellaâ„¢ pulmonary artery sensor system	2	2019
Device	crt-p	2	2010
Device	crt implant	2	2013
placebo	dapagliflozin matching placebo	2	2017
Behavioral	dash	2	2014
Drug	dopamine	2	2010
Device	doppler echocardiography	2	2020
Other	ecg	2	2014
Other	echocardiogram	2	2013
Drug	elamipretide	2	2016
Device	electrocardiogram	2	2012
Behavioral	electronic pill bottle	2	2016
Behavioral	engagement incentives	2	2016
Drug	entresto	2	2019
Behavioral	exercise only	2	2014
Behavioral	exercise training program	2	2015
Drug	fentanyl	2	2015
Drug	ferinject (ferric carboxymaltose)	2	2011
Behavioral	flexibility	2	2014
Diagnostic Test	frailty assessment	2	2018
Drug	furosemide injection solution for subcutaneous administration (80 mg)	2	2014
Drug	furosemide injection, usp	2	2014
Behavioral	gentle stretching	2	2019
Device	health coaching	2	2014
Behavioral	heart failure education	2	2020
Device	heartmate 3 lvas	2	2016
Device	heartpodâ„¢ system	2	2008
Device	heartwareâ® vas	2	2010
Procedure	hemodynamic measurements for crt device programming	2	2013
Behavioral	high intensity interval training	2	2014
Behavioral	hiit	2	2019
Drug	hno donor	2	2017
Behavioral	home-based exercise training	2	2011
Behavioral	home based education	2	2009
Drug	hydralazine	2	2010
Drug	hydrochlorothiazide	2	2019
Behavioral	icardia4hf	2	2020
Device	implantable cardioverter-defibrillator (icd)	2	2016
Device	implantable cardioverter defibrillator	2	2014
Drug	inactivated trivalent influenza vaccine	2	2013
Drug	insulin	2	2010
Behavioral	interval training	2	2015
Drug	intravenous insulin	2	2008
Drug	irbesartan	2	2006
Drug	kw-3902iv	2	2005
Other	laboratory biomarker analysis	2	2011
Drug	lcz 696	2	2019
placebo	lcz696 matching placebo	2	2016
Device	left ventricular assist system (lvas)	2	2014
Drug	levosimendan 2.5 mg	2	2018
Drug	levothyroxine	2	2016
Drug	liothyronine/placebo	2	2019
Drug	losartan	2	2013
Behavioral	low-intensity imt	2	2017
Other	low sodium diet	2	2018
Drug	medical management	2	2015
Device	medly	2	2017
Drug	metformin hydrochloride	2	2017
Drug	metolazone	2	2019
Drug	metoprolol	2	2018
Drug	metoprolol succinate	2	2013
Behavioral	mobile application	2	2019
Behavioral	moderate continuous training	2	2009
Behavioral	moderate intensity exercise training	2	2014
Behavioral	motivational interviewing	2	2017
Biological	mpc intramyocardial injection	2	2015
Procedure	mri	2	2015
Drug	neladenoson bialanate (bay1067197)	2	2016
Device	neuromuscular electrical stimulation	2	2020
Dietary Supplement	nicotinamide riboside	2	2018
Dietary Supplement	nitrate-deplete beetroot juice	2	2014
Drug	nitric oxide	2	2012
Other	no intervention	2	2011
Other	noninvasive ventilation	2	2014
Dietary Supplement	normal sodium diet	2	2018
Device	optimal medical therapy/crt/icd	2	2013
Device	optimal medical therapy/icd	2	2013
Device	optimizer system	2	2011
Drug	perhexiline	2	2009
placebo	placebo infusion	2	2014
Behavioral	pp-based health behavior intervention	2	2017
Other	preparation	2	2012
Behavioral	psychoeducational support	2	2015
Device	ptma (percutaneous transvenous mitral annuloplasty) implant	2	2007
Other	pulmonary function tests	2	2011
Procedure	pulmonary vein isolation	2	2020
Other	quality-of-life assessment	2	2011
Other	questionnaire	2	2011
Other	questionnaire administration	2	2011
Procedure	radiofrequency ablation	2	2008
Drug	ramipril	2	2009
Drug	relaxin	2	2007
Other	resistance exercise	2	2014
Drug	resveratrol	2	2013
Drug	rivaroxaban	2	2013
Drug	saccharomyces boulardii	2	2011
Drug	sacubitril/valsartan (lcz696)	2	2015
Device	saline solution	2	2019
Combination Product	sc2wear furosemide	2	2016
Drug	simvastatin	2	2010
Other	sip feeding with stable isotope infusion	2	2016
Drug	sodium nitrite	2	2016
Drug	somatotropin	2	2012
Drug	spironolactone / furosemide	2	2008
Drug	spironolactone 25mg	2	2010
Drug	splanchnic nerve anesthesia with a local anesthetic	2	2018
Device	standard biventricular pacing	2	2016
Other	standard imaging	2	2011
Drug	standard medical therapy	2	2011
Drug	standard of care for heart failure	2	2015
Other	strength training	2	2017
Behavioral	stretching	2	2014
Drug	subcutaneous insulin	2	2008
Drug	sugar pill	2	2009
Behavioral	support	2	2007
Behavioral	support partner	2	2016
Device	tele-monitoring	2	2015
Behavioral	telephone care	2	2005
Drug	testosterone undecanoate	2	2017
Drug	tezosentan	2	2007
Behavioral	therapeutic education	2	2016
Drug	torsemide	2	2017
Drug	trv120027	2	2011
Device	tvs	2	2017
Behavioral	usual heart failure care	2	2012
Drug	valsartan (lcz696)	2	2015
Drug	vericiguat (bay1021189) (1.25 mg)	2	2013
Drug	vericiguat (bay1021189) (5 mg)	2	2013
Behavioral	virtual visit	2	2018
Behavioral	walking	2	2014
Drug	warfarin	2	2016
Other	water immersion	2	2016
Device	NA	1	2018
Drug	- angiotensin conversing enzyme inhibitors: enalapril, captopril, lisinopril, ramipril, trandolapril.	1	2011
Other	“as usual” patient care management	1	2016
Drug	“drug:carvedilol”	1	2010
Drug	“drug:carvedilol”/“drug:ivabradine”	1	2010
Drug	“drug:ivabradine”	1	2010
Device	“in-clinic lvat”	1	2016
Drug	[11c]hed	1	2016
Drug	[13n]ammonia	1	2016
Drug	[18f]3f-phpg	1	2016
Drug	[18f]4f-mhpg	1	2016
Drug	[18f]fluorbetaox	1	2012
Other	[c11]acetate	1	2014
Other	[c11]acetate/hed pet	1	2014
Drug	0.005)	1	2007
Drug	0.01)	1	2007
Drug	0.5m sodium lactate	1	2013
Drug	0.9 % sodium chloride	1	2011
Drug	0.9% sodium chloride	1	2019
Drug	0.9% sodium chloride injection	1	2011
Drug	10 mg ir tablets	1	2018
Radiation	11c-metformin	1	2017
Behavioral	12-week education program	1	2005
Procedure	12-week supervised weight loss intervention	1	2011
Behavioral	12-week tai chi program	1	2005
Drug	14 n sodium nitrite	1	2015
Drug	14n nitrate	1	2016
Drug	15n nitrate	1	2016
Device	2-lead crt defibrillator system implantation	1	2018
Drug	2.5 times the diuretics dose	1	2016
Drug	2:1 epa	1	2014
Drug	2:1 epa/dha	1	2014
Drug	25 mg omecamtiv mecarbil	1	2016
Drug	3 hours intravenous dobutamine	1	2010
Biological	3 x 10e13vg nan-101	1	2019
Drug	30 ng	1	2010
Drug	37.5 mg omecamtiv mecarbil	1	2016
Procedure	3d echo-guided lv lead placement	1	2011
Device	4	1	2005
Drug	4 mg elamipretide	1	2016
Drug	40 mg elamipretide	1	2016
Device	4he crt-d	1	2005
Drug	5% glucose injection	1	2014
Drug	50 mg omecamtiv mecarbil	1	2016
Procedure	6 minute walk test	1	2015
Behavioral	6 months readmission rate to hospital	1	2006
Device	70cc tah-t for destination therapy	1	2014
Drug	99mtc-pyp	1	2018
Other	a motivational intervention	1	2007
Device	âµcor	1	2018
Procedure	aadc therapy	1	2015
Genetic	aav1	1	2012
Genetic	aav1/serca2a (mydicar)	1	2012
Device	abbott medicalâ® crt device with biventricular stimulation (biv)	1	2019
Device	abbott medicalâ® crt device with syncavtm stimulation function	1	2019
Other	abdominal magnetic resonance imaging	1	2012
Device	ablation	1	2020
Drug	ac2592	1	2004
Dietary Supplement	acacia gum	1	2018
Device	accelerometer	1	2016
Device	accelerometer mode on biotronik crt-d	1	2015
Behavioral	acces - adjusting to chronic conditions with education	1	2007
Behavioral	acces - adjusting to chronic conditions with education/support	1	2007
Behavioral	access	1	2010
Device	access arm	1	2008
Device	accucinchâ® ventricular repair	1	2018
Device	ace compression wrap	1	2019
Drug	ace inhibitor - ramipril, enalapril, captopril, perindopril, lisinopril	1	2006
Drug	acei/arb	1	2019
Drug	acetylsalicylic acid (asa) therapy	1	2016
Drug	acipimox	1	2007
Device	acoustic cardiography	1	2007
Behavioral	acp	1	2014
Behavioral	acp video program	1	2015
Device	acrt off	1	2019
Device	acrt on	1	2019
Biological	acrx-100	1	2010
Other	action control education	1	2008
Procedure	activation of the vagus nerve stimulator	1	2007
Dietary Supplement	active lozenge	1	2017
Drug	active medication alone	1	2001
Behavioral	active patient engagement	1	2019
Other	active phototherapy	1	2017
Behavioral	activity feedback	1	2014
Behavioral	activity feedback/encouragement	1	2014
Drug	actos	1	2007
Diagnostic Test	acute hemodynamic study	1	2020
Other	acute response assessment	1	2013
Drug	ad5.hac6	1	2008
Device	adaptive crt (acrt)	1	2009
Procedure	adaptive servo-ventilation post-operative treatment for 6 months	1	2012
Device	adaptive servoventilation (asv)	1	2010
Device	additional endocardial	1	2010
Device	additional endocardial/epicardial lv lead	1	2010
Other	additional phone calls	1	2010
Behavioral	adherence measurements	1	2016
Behavioral	adherence measures	1	2014
Behavioral	adhesion-hf	1	2014
Other	adjust to illness	1	2011
Drug	adrecizumab	1	2020
Drug	adrenergic beta antagonists	1	1999
Other	advanced cardiac imaging	1	2010
Behavioral	advanced care planning program of health decisions	1	2020
Other	aerobic-inspiratory	1	2016
Other	aerobic-resistance	1	2016
Other	aerobic-resistance-inspiratory	1	2016
Behavioral	aerobic exercise	1	2015
Other	aerobic exercise in treadmill	1	2016
Behavioral	aerobic exercise intervention	1	2018
Other	aerobic exercise more force	1	2019
Behavioral	aerobic exercise program	1	2007
Other	aerobic/inspiratory training	1	2018
Other	aerobic/strength training	1	2013
Procedure	af ablation	1	2008
Drug	afterload decrement	1	2007
Drug	ai-700	1	2005
Other	ai-enabled ecg-based screening tool	1	2019
Device	airsenseâ„¢ 10 autoset	1	2016
Drug	albuterol	1	2016
Drug	alcoholic chlorhexidine	1	2013
Drug	alcoholic povidone iodine	1	2013
Drug	aldosterone antagonists - spironolactone	1	2006
Drug	aleglitazar	1	2007
Device	alexa	1	2018
Device	alexa/	1	2018
Device	alfapump dsr system	1	2019
Device	algisyl-lvr	1	2011
Drug	aliskiren 150 mg	1	2010
Drug	aliskiren 300 mg	1	2010
Other	all antidiabetic drugs will be appliable	1	2010
Other	all patients	1	2017
Biological	allogeneic adipose derived stem cells (cscc_asc)	1	2014
Biological	allogeneic derived cells	1	2016
Drug	allogeneic mesenchymal bone marrow cells (ambmc)	1	2015
Biological	allogeneic mesenchymal precursor cells (mpc)	1	2014
Biological	allogeneic stem cells implantation	1	2012
Behavioral	ambio health remote monitoring	1	2017
Other	ambulatory blood pressure monitoring	1	2012
Other	ambulatory visit	1	2018
Drug	amg 423	1	2015
Drug	amg 986	1	2017
Drug	anakinra (high dose)	1	2013
Drug	anakinra (standard dose)	1	2013
Drug	anakinra (weeks 1-2)	1	2013
Drug	anakinra (weeks 3-12)	1	2013
Device	anger camera	1	2015
Drug	angiotensin-(1-7)	1	2016
Behavioral	animal-assisted therapy	1	2006
Procedure	anterior pericardiotomy	1	2017
Diagnostic Test	anthropometry	1	2020
Diagnostic Test	anthropometry/body composition	1	2020
Drug	anti-arrhythmic therapy	1	2015
Device	anti-factor xa guided heparin management	1	2017
Drug	anti-myocardial remodeling	1	2016
Drug	anti-myocardial remodeling,anti-acute heart failure	1	2016
Other	anticoagulation care	1	2017
Dietary Supplement	antioxidant	1	2017
Behavioral	app group	1	2018
Device	appli	1	2019
Behavioral	application of a management action plan	1	2005
Device	application of quadripolar	1	2012
Device	application of quadripolar / bipolar lv electrodes	1	2012
Device	aptt guided heparin management	1	2017
Device	aquadex flexflow system	1	2019
Device	aquadex flexflow system/bva-100	1	2019
Device	aquadex system	1	2005
Drug	arb	1	2019
Device	ardian	1	2012
Device	arfi measurement	1	2010
Device	assessment of burden of chronic conditions (abcc)-tool	1	2019
Diagnostic Test	assessment of cardiac sympathetic innervation by 123i-mibg	1	2018
Other	assessment of sleep apnea syndrome	1	2012
Other	assistance by a specialized hf nurse	1	2016
Device	asv	1	2007
Drug	atacand tablet	1	2012
Other	atrial fibrillation	1	2014
Procedure	atrial fibrillation ablation	1	2008
Device	atrial flow regulator (occlutechâ® afr device)	1	2020
Device	atrial overdrive pacing	1	2005
Device	atrial shunt	1	2019
Device	atrial support pacing through cardiac resynchronization therapy. device: renewal family of crt-d devices	1	2005
Device	atrial synchronous bi-ventricular pacing	1	2006
Procedure	atrio ventricular junction ablation with radio-frequency	1	2010
Device	attain stability quad left ventricular pacing lead	1	2017
Behavioral	attention control (ac) condition	1	2006
Behavioral	attention control group	1	2012
placebo	attention placebo	1	2005
Device	auto adjusting bi-level positive airway pressure device	1	2008
Procedure	autologous bone marrow intracoronary infusion	1	2009
Biological	autologous cell therapy	1	2015
Biological	autologous human bone marrow cells (hbmcs)	1	2008
Biological	autologous human mesenchymal cells (hmscs)	1	2008
Device	automated medication dispensing device	1	2012
Device	automatic fluid shunt system	1	2009
Device	autotitrating positive airway pressure	1	2008
Device	av delay programming through cardiac resynchronization therapy	1	2008
Procedure	av nodal ablation	1	2012
Drug	avanclia (rosiqlitazone)	1	2003
Drug	avandia (rosiglitazone)	1	2003
Procedure	avatar-af ablation	1	2015
Device	avd-glittre test	1	2015
Drug	azd4831	1	2020
Drug	azd8601	1	2017
Drug	azimilide 2hcl	1	2008
Drug	azosemide	1	2006
Drug	b-type natriuretic peptide (bnp)	1	2005
Other	balance intervention	1	2015
Other	balance training	1	2019
Other	basic metabolic panel	1	2015
Drug	bay 1753011	1	2019
Drug	bay1067197	1	2014
Drug	bay1067197 (10 mg)	1	2014
Drug	bay1067197 (treatment 2)	1	2013
Drug	bay60-4552	1	2007
Drug	bay94-8862 (1.25mg)	1	2012
Drug	bay94-8862 (10mg)	1	2012
Drug	bay94-8862 (2.5mg)	1	2012
Drug	bay94-8862 (5mg)	1	2012
Drug	bay94-8862 (7.5mg)	1	2012
Drug	bc 007	1	2019
Dietary Supplement	bcaa supplementation	1	2014
Dietary Supplement	beetroot juice (brj)	1	2012
Behavioral	behavior)	1	2006
Behavioral	behavioral	1	2006
Behavioral	behavioral activation therapy	1	2018
Behavioral	behavioral management	1	2001
Behavioral	behavioral psychotherapy	1	2006
Behavioral	behavioral support	1	2015
Behavioral	benson relaxation exercise	1	2020
Drug	benzbromarone (drug)	1	2007
Behavioral	besmile-hf program	1	2017
Other	best medical treatment	1	2008
Drug	beta-blocker treatment	1	2005
Drug	beta-blockers including carvedilol	1	2006
Drug	beta-hydroxy-butyrate	1	2018
Drug	beta adrenergic blockers	1	2000
Drug	beta blocker	1	2010
Drug	beta blocker (bb) - metoprolol, bisoprolol, carvedilol	1	2006
Drug	beta blocker/digoxine/amiodarone	1	2010
Drug	beta blockers	1	2014
Device	beutel tm	1	2008
Device	bi-ventricular pacing	1	2017
Device	bi ventricular pacing	1	2009
Drug	bia-5-453	1	2017
Drug	bidil	1	2002
Drug	bidil immediate release (ir)	1	2015
Drug	bidil xr	1	2015
Procedure	bilateral surgical resection of carotid bodies	1	2013
Device	bilevel	1	2014
Device	bilevel positive pressure airway	1	2016
Device	biobeat wrist watch	1	2020
Other	bioimpedentiometry	1	2015
Biological	biomarker	1	2017
Other	biomarker guided discharge algorithm	1	2017
Device	biomaterial	1	2016
Other	biotechcoachforall	1	2019
Device	biotronik vision guidewire	1	2017
Procedure	bip group	1	2011
Device	bipolar lv electrodes	1	2012
Device	biv icd	1	2010
Device	biventricular pacemaker	1	2017
Device	biventricular pacemaker with epicardial left ventricular lead	1	2007
Device	biventricular pacing	1	2009
Procedure	blood collection	1	2019
Device	blood flow restriction	1	2017
Device	blood pressure	1	2015
Other	blood sampling for biomarker assessment	1	2015
Other	blood sampling/quality of life questionnaire.	1	2018
Other	blood test	1	2011
Procedure	blood volume analysis	1	2019
Procedure	blood volume measurement	1	2014
Other	blood withdrawal	1	2017
Device	bmac infusion	1	2011
Drug	bms-986224	1	2018
Drug	bms-986231 formulation a	1	2019
Drug	bms-986231 formulation b	1	2019
Drug	bms-986231 formulation c	1	2019
Drug	bms-986231 formulation d	1	2019
placebo	bms-986231 placebo	1	2016
Drug	bnp	1	2009
Device	bnp heartcheck	1	2014
Procedure	bnp, saag, ascites total protein, echocardiography	1	2010
Drug	bnp/pde-v	1	2009
Diagnostic Test	body composition	1	2020
Device	body composition analysis inbody scale	1	2011
Device	body surface ecg mapping	1	2013
Procedure	bone marrow transplantation	1	2005
Dietary Supplement	boost high protein	1	2013
Drug	bosentan	1	2009
Device	boss device	1	2017
Drug	bq-123	1	2014
Device	brain natriuretic peptide levels – diagnostic testing	1	2007
Other	breathing technique	1	2017
Behavioral	brief cognitive therapy intervention	1	2011
Behavioral	brief educational intervention (bei)	1	2006
Behavioral	brief treatment for insomnia	1	2018
Drug	bucindolol hydrochloride	1	2013
Drug	bumetanide 1 mg	1	2018
Behavioral	burst physical activity	1	2017
Device	bva-100	1	2019
Biological	c-cure	1	2008
Biological	c-kit	1	2015
Biological	c-kit/ cells	1	2015
Device	c-pulseâ„¢ (implantable counterpulsation therapy)	1	2008
Device	c-pulseâ® system counterpulsation	1	2012
Procedure	cabg	1	2001
Procedure	cabg surgery/med	1	2001
Procedure	cabg/med/svr	1	2001
Drug	canagliflozin	1	2016
Drug	canagliflozin 100 mg	1	2020
Drug	candemore tablet	1	2012
Drug	candesartan up to 32 mg daily	1	2006
Drug	canrenone	1	2006
Drug	captopril	1	2006
placebo	carbohydrate placebo	1	2019
Other	cardiac	1	2012
Procedure	cardiac catheterization	1	2020
Other	cardiac computed tomography	1	2016
Other	cardiac exercise training	1	2016
Other	cardiac function indices during wakefulness	1	2015
Diagnostic Test	cardiac magnetic resonance	1	2017
Diagnostic Test	cardiac magnetic resonance, echocardiogram, blood investigation (nt-probnp)	1	2019
Diagnostic Test	cardiac magnetic resonance, echocardiogram, blood investigation (nt-probnp), cardiac catheterization	1	2019
Device	cardiac pacing	1	2017
Device	cardiac pacing/impedance measurement system	1	2017
Other	cardiac rehabilitation clinic	1	2014
Device	cardiac resynchronisation therapy	1	2015
Device	cardiac resynchronization pacemaker (insync sentry	1	2008
Device	cardiac resynchronization pacemaker (insync sentry/concerto, medtronic, minneapolis, mn,usa) with two intracardiac leads	1	2008
Device	cardiac resynchronization pacing	1	2007
Device	cardiac resynchronization therapy-defibrillator (crt-d)	1	2010
Device	cardiac resynchronization therapy -defibrillator (range paradym, livanova, clamart, france)	1	2016
Device	cardiac resynchronization therapy (crt) device	1	2005
Device	cardiac resynchronization therapy (crt) device/implantable cardioverter defibrillator (icd) with crt	1	2005
Procedure	cardiac resynchronization therapy (crt) implantation	1	2010
Device	cardiac resynchronization therapy (st. jude qaudripolar lv lead)	1	2015
Device	cardiac resynchronization therapy defibrillator device	1	2017
Procedure	cardiac resynchronization therapy device implantation	1	2013
Device	cardiac resynchronization therapy device with closed loop stimulation (cls)	1	2017
Device	cardiac resynchronization therapy implant	1	2009
Device	cardiac resynchronization therapy implantation	1	2016
Device	cardiac resynchronization therapy pacemaker	1	2017
Device	cardiac resynchronization therapy pacemaker (crt-p)	1	2018
Device	cardiac resynchronization therapy with	1	2005
Device	cardiac resynchronization therapy with multipoint pacing	1	2014
Device	cardiac resynchronization therapy with/without defibrillator	1	2005
Device	cardiac resynchronization therapy/implantable cardioverter defibrillator	1	2005
Other	cardiac/abdominal magnetic resonance imaging	1	2012
Other	cardio-respiratory management model	1	2016
Drug	cardiocell	1	2018
Device	cardiocom	1	2015
Device	cardiogoniometry	1	2016
Biological	cardiology stem cell centre adipose stem cell (cscc_asc)	1	2015
Device	cardiomems hf pressure measurement system	1	2010
Device	cardiomems hf system	1	2016
Device	cardiomemsâ„¢ hf system	1	2017
Diagnostic Test	cardiopulmonary exercise testing	1	2019
Other	cardiopulmonary max exercise test	1	2015
Device	cardiopulmonary test	1	2015
Device	cardiospec	1	2010
Device	cardiospire (respirix) device	1	2019
Behavioral	care guide	1	2010
Behavioral	care management program “promic”	1	2015
Other	care4todayheart failure platform	1	2020
Device	carmat tah	1	2016
Procedure	carotid body excision	1	2012
Other	carotid ultrasound	1	2008
Drug	carperitide	1	2005
Drug	carvedilol-immediate release (ir) 2.5 mg tablet	1	2008
Drug	carvedilol-ir 10 mg tablet	1	2008
Drug	carvedilol controlled release	1	2006
Drug	carvedilol immediate release	1	2006
Drug	carvedilol/nurse management	1	2006
Other	casa intervention	1	2012
Other	case management	1	2010
Behavioral	case management using advanced nurse practitioners	1	2005
Procedure	catheter ablation for persistent atrial fibrillation	1	2009
Procedure	catheterization, swan-ganz	1	1999
Procedure	catheters	1	2015
Drug	cd-np (chimeric natriuretic peptide)	1	2008
Drug	cdr132l	1	2019
Device	ce marked philips motiva system	1	2014
Device	celacadeâ„¢ system	1	2005
Other	cell phone	1	2016
Biological	cell therapy	1	2016
Biological	cells	1	2015
Device	centrimag rvas placement	1	2012
Device	centrimag ventricular assist system	1	2009
Other	cf-lvad pump speed baseline.	1	2014
Other	cf-lvad pump speed increased.	1	2014
Other	change of treatment plan	1	2018
Other	checklist cohort	1	2011
Other	chemosensitivity test	1	2015
Other	chest radiograph	1	2011
Other	chest radiography	1	2014
Behavioral	chf self-management education (web-based education)	1	2001
Device	chiara-system	1	2017
Drug	chlorothiazide	1	2015
Drug	chlorothiazide injection	1	2018
Device	chromed monitoring system	1	2013
Device	chronic heart failure monitoring system	1	2005
Device	chronicle implantable hemodynamic monitor	1	2008
Procedure	circuit training	1	2005
Device	circulite synergy pocket circulatory assist device	1	2009
Other	classical cardiac rehabilitation	1	2019
Behavioral	classical massage	1	2020
Other	clean air	1	2013
Drug	clevidipine	1	2008
Other	clinical assessment	1	2007
Other	clinical audit	1	2016
Other	clinical audit/feedback	1	2016
Other	clinical evaluation	1	2019
Other	clinical evaluation in home monitoring program	1	2011
Other	clinical pathways	1	2007
Other	clinician nudge	1	2018
Other	clinician nudge/opt out approach for ahcah liaison visit	1	2018
Drug	clonidine patch	1	2009
Drug	clopidogrel 75	1	2000
Drug	clopidogrel 75 mg daily x 2 weeks	1	2012
Drug	clr325	1	2016
Device	cls mode on biotronik crt-d	1	2015
Diagnostic Test	cmr	1	2017
Device	cobas h232 (roche diagnostics)	1	2016
Dietary Supplement	cocoavia	1	2014
Behavioral	cognitive behavior therapy	1	2009
Behavioral	cognitive behavioral therapy	1	2005
Behavioral	cognitive behavioral therapy (cbt)	1	2013
Behavioral	cognitive behavioral therapy for insomnia	1	2016
Behavioral	cognitive behavioral therapy for insomnia (cbt-i)	1	2016
Behavioral	cognitive behaviour therapy	1	2012
Behavioral	cognitive retraining	1	2014
Other	cognitive testing	1	2016
Behavioral	cognitive training	1	2015
Other	cohort	1	2010
Device	cold cardioplegia solution	1	2009
Behavioral	collaborative care for depression	1	2014
Behavioral	collaborative care for heart failure	1	2014
Other	collaborative care to alleviate symptoms	1	2011
Other	collaborative care to alleviate symptoms/adjust to illness	1	2011
Behavioral	collaborative care treatment	1	2009
Procedure	collection of discarded heart tissue	1	2017
Behavioral	color-coded cue cards	1	2016
Drug	combination therapy with acetazolamide	1	2013
Drug	combination therapy with acetazolamide/low-dose loop diuretics	1	2013
Other	combined	1	2018
Other	combined aerobic training	1	2017
Other	combined aerobic/resistance physical training program	1	2015
Behavioral	combined aerobic/strength exercise intervention	1	2018
Other	combined ambulatory visit	1	2018
Behavioral	combined psychotherapy	1	2011
Behavioral	combined psychotherapy/illness management	1	2011
Other	combined strength training	1	2017
Other	comfort default ad forms	1	2013
Behavioral	commitment nudge	1	2018
Behavioral	communication training for cardiologists.	1	2011
Other	community of practice facilitation	1	2013
Other	community paramedicine	1	2014
Behavioral	comorbid illness management	1	2006
placebo	comparator placebo (unspecified)	1	2008
placebo	comparator: placebo	1	2008
Device	compare vvi mode versus ddd bifocal stimulation through crossover randomization	1	2018
Other	composition of body mass by dual x-ray absorptiometry	1	2012
Behavioral	comprehensive quality improvement program (qip)	1	2010
Behavioral	computer reminders	1	2001
Behavioral	computerized cognitive training with brain hq	1	2017
Behavioral	computerized crossword puzzles	1	2017
Other	concentric	1	2014
Other	concentric aerobic exercise	1	2014
Other	concentric/eccentric exercise sessions	1	2014
Device	concerto, medtronic, minneapolis, mn,usa) with two intracardiac leads	1	2008
Device	conductance catheter	1	2016
Device	conductance catheterization	1	2014
Device	contak renewal 2	1	2005
Device	contak renewal 2/4/4he crt-d	1	2005
Device	contak renewal 3 avt	1	2005
Other	continues aerobic training	1	2013
Other	continuing medical education	1	2019
Other	continuous aerobic training	1	2020
Device	continuous positive airway pressure	1	2013
Behavioral	continuous training	1	2015
Other	control diet	1	2014
Other	control group (standard care)	1	2017
Biological	control procedure	1	2016
Device	controlled cardiac reloading through lvad speed adjustment	1	2017
Drug	controlled withdrawal of beta-blockers	1	2019
Other	controlled, supervised exercise protocol	1	2014
Other	conventional	1	2020
Device	conventional 3-lead crt defibrillator system implantation	1	2018
Procedure	conventional af ablation	1	2015
Device	conventional cardiac resynchronization	1	2009
Other	conventional care	1	2014
Device	conventional crt	1	2016
Other	conventional interval training	1	2019
Other	conventional medical therapy for heart failure	1	2008
Other	conventional medicines (oxygen therapy, alfa interferon via aerosol inhalation,/lopinavir/ritonavir)/traditional chinese medicines (tcms) granules	1	2008
Other	conventional rhythm control	1	2009
Behavioral	coping effectiveness training (cet)	1	2015
Behavioral	coping skills training	1	2009
Drug	coq10	1	2017
Device	cordellaâ„¢ heart failure system	1	2017
Device	cordiva system (r)	1	2014
Device	corollaâ„¢ taa device	1	2015
Procedure	coronary artery bypass grafting	1	2009
Other	coronary artery disease	1	2013
Device	corox otw steroid left ventricular lead	1	2006
Behavioral	cp	1	2007
Device	cpap therapy	1	2008
Other	cpr	1	2013
Drug	crataegus special extract ws 1442	1	2006
Drug	crd-102	1	2017
Drug	crestor	1	2005
Other	crt-d full remote monitoring	1	2016
Procedure	crt-d implantation	1	2018
Device	crt-d re-programming	1	2018
Other	crt-d standard remote monitoring	1	2016
Device	crt-d with home monitoring feature activated	1	2007
Device	crt-d with home monitoring feature deactivated	1	2007
Device	crt-d/lv lead (quartetâ„¢ lead/promote qâ® device system)	1	2009
Procedure	crt-p implantation	1	2018
Device	crt-p/crt-d	1	2010
Other	crt-p/crt-d full remote monitoring	1	2016
Other	crt-p/crt-d standard remote monitoring	1	2016
Device	crt-sonr 9770	1	2010
Device	crt 9750	1	2010
Device	crt algorithm	1	2016
Device	crt device implant with multipoint pacing	1	2013
Device	crt pacemaker	1	2016
Device	crt with lv-only pacing	1	2017
Device	crt with lv-only pacing / bi-ventricular pacing	1	2017
Device	crt with multipoint pacing	1	2014
Device	crt with triple site ventricular stimulation	1	2009
Device	crt/navh	1	2016
Procedure	cryoballoon ablation	1	2018
Biological	cscc_asc	1	2016
Other	ct-scan	1	2019
Procedure	ct angiography	1	2006
Drug	custodiol	1	2015
Drug	custodiol-n	1	2015
Drug	cxl-1020	1	2010
Drug	cxl-1020 dose for echo cohort a	1	2010
Drug	cxl-1020 doses for echo cohort b	1	2010
Drug	cxl-1427	1	2014
Drug	cxl-1427 ascending dose	1	2016
Drug	cxl-1427 descending dose	1	2016
Device	czt camera (d-spect)	1	2015
Drug	d-ribose oral powder	1	2017
Other	daily ischemic conditioning treatment	1	2014
Other	daily life.	1	2013
Behavioral	daily physical activity	1	2014
Diagnostic Test	daily pocus exam	1	2019
Behavioral	daily weight measured by digital scale	1	2011
Behavioral	daily weight measured by digital scale/symptom reporting	1	2011
Other	danger signs of heart failure videos	1	2018
Drug	dapagliflozin 10 mg [farxiga]	1	2019
Drug	dapagliflozin 10mg oral tablet	1	2017
Drug	dapansutrile capsules	1	2017
Other	dash eating pattern	1	2018
Behavioral	dash/sodium-restricted diet (srd)	1	2009
Other	dash/srd	1	2014
Procedure	dcd heart transplantation using nrp	1	2020
Procedure	dce-mri scans	1	2014
Procedure	ddd-60	1	2014
Procedure	ddd-80	1	2014
Other	decision support systems, clinical	1	2019
Device	defibrillator	1	2018
Device	defibrillators, implantable	1	1999
Drug	definity	1	2017
Other	delayed mbs intervention	1	2015
Drug	demadex 20mg tablet	1	2017
Other	deuterium oxide dilution	1	2015
Device	device implantation	1	2008
Device	device programming	1	2009
Device	device programming of crt pacemaker	1	2018
Device	device programming of crt pacemaker/defibrillator	1	2018
Other	device programming: nominal	1	2011
Device	device therapy for heart failure	1	2013
Behavioral	device triggered remote telephone contact because of care alert	1	2008
Device	device: attain performa pacing lead (along with a standard crt-d system)	1	2012
Radiation	dexa	1	2015
Radiation	dexa bone scan	1	2015
Drug	dexamethasone	1	2014
Drug	dexmedetomidine	1	2015
Drug	dha	1	2014
Dietary Supplement	dha) alone	1	2014
Device	diagnostic electrophysiology catheter	1	2010
Procedure	diagnostic ultrasound	1	2016
Device	diaphragm ultrasound	1	2015
Procedure	diastolic pressure at exercise	1	2012
Behavioral	diet	1	2009
Behavioral	diet/exercise	1	2009
Behavioral	dietary counseling	1	2008
Dietary Supplement	dietary intervention	1	2009
Other	dietary manipulation	1	2020
Other	dietary plan with controlled amount of sodium	1	2015
Behavioral	dietary,	1	2015
Behavioral	dietary, aerobic	1	2015
Behavioral	dietary, aerobic/resistance training	1	2015
Behavioral	dietary,/aerobic exercise	1	2015
Behavioral	dietetic group sessions	1	2014
Device	different programming of a crt defibrillator	1	2017
Device	diffusion tensor mri (dti)	1	2016
Other	digital engagement	1	2017
Other	digital talking scale	1	2013
Drug	digitalis	1	1999
Drug	digoxin 0.25 mg	1	2019
Other	digoxin dosing per nomogram	1	2009
Drug	digoxine	1	2010
Other	direct engagement	1	2017
Behavioral	discharge education of chinese medicine	1	2018
Other	discussion	1	2016
Behavioral	discussion group	1	2012
Other	disease management	1	2007
Other	disease management program	1	2010
Other	disease management/tele-monitoring	1	2007
Other	disease program management	1	2007
Drug	diuretic	1	2017
Drug	diuretic increase (di)	1	2017
Drug	diuretic suspension (ds)	1	2017
Drug	diuretic/medication suspension (dms)	1	2017
Other	dna extraction	1	2010
Other	dna extraction/genotyping	1	2010
Device	docview	1	2015
Device	doppler-echocardiography	1	2007
Device	doppler-echocardiography/acoustic cardiography	1	2007
Device	doraya catheter	1	2017
Other	doubly labelled water	1	2008
Other	doubly labelled water/questionnaire	1	2008
Device	dr 9550	1	2010
Behavioral	driving decision aid	1	2019
Drug	drug therapy for heart failure	1	2013
Other	drug therapy for hf	1	2006
Behavioral	dt lvad decision support intervention	1	2015
Procedure	dt pressure measurement	1	2009
Device	dual (atrial	1	2006
Device	dual (atrial/ventricular) implantable defibrillator	1	2006
Device	dynaport move monitor	1	2018
Other	dynasdy	1	2015
Dietary Supplement	eaa mixture	1	2018
Procedure	early intensive care bundle	1	2018
Combination Product	early intra-aortic balloon pump (iabp) implantation	1	2020
Other	early warning system monitoring.	1	2012
Device	easytrak 2 lead	1	2005
Device	easytrak 3 downsize lead	1	2006
Device	easytrak 3 left ventricular pacing lead	1	2005
Device	easytrak 4 steerable lv lead	1	2005
Device	easytrak epi lead	1	2005
Other	eccentric aerobic exercise	1	2014
Other	eccentric exercise sessions	1	2014
Other	eccentric rehabilitation sessions	1	2018
Device	ecg belt research system	1	2018
Device	ecg vest optimization	1	2016
Other	ecg/clinical evaluation in home monitoring program	1	2011
Device	echo	1	2009
Device	echo-guided left ventricular lead placement	1	2005
Device	echo-optimization	1	2019
Other	echo optimisation	1	2010
Other	echocardiogram/sonr	1	2011
Device	echocardiograms	1	2015
Other	echotracking	1	2012
Behavioral	education only	1	2010
Behavioral	education with teach-back method	1	2018
Behavioral	education/care guide	1	2010
Behavioral	educational intervention	1	2006
Behavioral	educational program	1	2001
Other	educational structured counseling	1	2015
Other	educational training regarding heart failure	1	2009
Other	educational video and	1	2017
Other	educational video and/or handout	1	2017
Other	educational website (in addition to usual care).	1	2012
Other	effect of cpap on respiratory work	1	2015
Other	effect of cpap on respiratory work/cardiac function indices during wakefulness	1	2015
Behavioral	effects of a 2-week dash	1	2017
Behavioral	effects of a 2-week dash/srd intervention vs. control diet on hfpef functional cardiovascular risk factors	1	2017
Behavioral	ehr-based clinician jumpstart	1	2020
Procedure	elastography function shearwave imaging	1	2015
Device	electrical	1	2014
Device	electrical muscle devise	1	2018
Device	electrical/magnetic nerve stimulators	1	2014
Device	electrocardiographic optimization of the interventricular pacing delay according to qrs width	1	2010
Behavioral	electronic alert	1	2019
Behavioral	electronic prescription	1	2018
Device	electronic repositioning	1	2008
Procedure	electrophysiological study	1	2013
Device	elevated night pacing off	1	2017
Device	elevated night pacing on	1	2017
Drug	empagliflozin 10mg	1	2017
Drug	empagliflozin 10mg tab	1	2017
Drug	empagliflozin 25 mg	1	2019
Drug	empagliflozin 25mg	1	2017
Behavioral	enable chf-pc	1	2017
Behavioral	encompass intervention	1	2017
Behavioral	encouragement	1	2014
Device	endocardial left ventricular pacing	1	2011
Behavioral	endorsed evidence summaries	1	2005
Behavioral	endurance training	1	2009
Other	energy conservation	1	2019
Other	energy conservation/problem solving therapy	1	2019
Behavioral	enhanced education	1	2012
Device	enhanced external counterpulsa	1	2018
Behavioral	enhanced se	1	2005
Behavioral	enhanced self-efficacy (se)	1	2005
Other	enhanced standard management	1	2013
Behavioral	enhanced training	1	2012
Behavioral	enhanced usual care group	1	2012
Other	ensite navx system	1	2007
Drug	entrestoâ„¢ 49mg-51 mg tablet	1	2018
Other	enzyme-linked immunosorbent assay	1	2011
Drug	epclusa	1	2017
Device	epicardial implantation of cardiac resynchronization therapy device	1	2009
Device	epicardial lv lead	1	2010
Dietary Supplement	epicatechin-enriched dark chocolate	1	2012
Device	equiliaâ® vagal nerve stimulation	1	2014
Drug	er torsemide 20mg tablet	1	2017
Procedure	eric protocol	1	2018
Drug	ertugliflozin	1	2018
Drug	erythropoietin administration	1	2006
Drug	erythropoietin alpha	1	2006
Drug	etiologic treatment,anti-myocardial remodeling	1	2016
Drug	etiological, anti-remodeling	1	2016
Drug	etiological, anti-remodeling/symptom treatment	1	2016
Device	europe: autoset cs (usa: vpap adapt sv)	1	2008
Device	evaheart left ventricular assist system (lvas)	1	2010
Behavioral	evaluation of quality of life health related	1	2019
Drug	evidence-based medications	1	2019
Drug	evidence-based medications vs. high-dose hydralazine	1	2019
Drug	evidence-based medications vs. high-dose hydralazine / evidence-based medications	1	2019
Drug	evolocumab	1	2018
Drug	exenatide	1	2008
Behavioral	exercise adherence	1	2007
Behavioral	exercise group	1	2019
Other	exercise protocol no supervised	1	2014
Other	exercise rehabilitation	1	2018
Other	exercise test	1	2018
Other	exercise training and	1	2013
Other	exercise training and/or crt	1	2013
Behavioral	exercise training in heart failure with hiit	1	2018
Other	exercise training intervention	1	2017
Other	exercise training of high intensity	1	2020
Other	exercise training of moderate intensity	1	2020
Other	exercise with	1	2020
Other	exercise with/without codeine	1	2020
Behavioral	exercise, nutritional	1	2015
Behavioral	exercise, nutritional/pharmaceutical counseling	1	2015
Behavioral	exercise/cognitive retraining	1	2014
Other	exercise/cognitive testing	1	2016
Other	expanded technology disease management	1	2014
Device	experimental	1	2011
Device	experimental 2	1	2011
Procedure	experimental lung function test	1	2007
Device	external electrocardioversion	1	2014
Behavioral	facilitator-based intervention	1	2018
Behavioral	family education	1	2005
Behavioral	family focused nursing	1	2011
Behavioral	family partnership intervention (fpi)	1	2005
Behavioral	family swap intervention with mini ipad	1	2015
Behavioral	fampalcare	1	2019
Device	fatigue	1	2020
Device	feasibility of wearing a readiband to monitor sleep	1	2020
Device	feasibility of wearing a readiband to monitor sleep/fatigue	1	2020
Other	feedback	1	2016
Drug	ferinject â® (ferric carboxymaltose)	1	2007
Drug	ferric carboxymaltose 50mg	1	2017
Drug	ferric carboxymaltose 50mg/ml inj 15ml	1	2017
Drug	ferric carboxymaltose infusion	1	2016
Drug	ferric carboymaltose	1	2017
Drug	ferric polymaltose hydroxide complex im	1	2019
Drug	ferroglycine sulfate	1	2019
Drug	ferrous sulfate	1	2016
Other	fes	1	2015
Other	filtered diesel exhaust	1	2013
Other	final evaluation	1	2014
Device	finapres nova device (fms system)	1	2015
Drug	finerenone (bay94-8862)	1	2013
Device	fire1 system	1	2019
Drug	fish oil	1	2014
Dietary Supplement	fish oil (epa	1	2014
Dietary Supplement	fish oil (epa/dha) alone	1	2014
Drug	fish oil supplement	1	2004
Drug	fish oil supplementation	1	2012
Device	fitbit charge 2	1	2019
Behavioral	five wishes form	1	2018
Device	fixed av delay	1	2019
Procedure	flexibility/toning	1	2005
Device	florence device	1	2018
Biological	flu vaccine	1	2008
Dietary Supplement	fluid restriction	1	2009
Device	fluid status monitoring (optivolâ„¢)	1	2006
Behavioral	fluid watchers	1	2006
Behavioral	fluid watchers lite educational intervention	1	2006
Behavioral	fluid watchers/educational intervention	1	2006
Other	fluoroscopy venography	1	2017
Diagnostic Test	focused ultrasound diagnostics	1	2018
Other	follow-up	1	2013
Drug	frozen plasma product, human	1	2017
Drug	frusemide	1	2017
Other	frusemide iv infusion	1	2019
Other	frusemide iv shots	1	2019
Radiation	ftha, fdg pet imaging.	1	2012
Behavioral	full simulation	1	2013
Behavioral	full simulation/education	1	2013
Diagnostic Test	functional capacity tests	1	2020
Behavioral	functional circuit training	1	2010
Behavioral	functional circuit training/lifestyle counseling	1	2010
Other	functional electrical stimulation	1	2013
Other	functional electrical stimulation of peripheral muscles	1	2013
Other	functional training	1	2017
Other	functionnal electrostimulation (fes)	1	2012
Drug	furosemide-continuous infusion	1	2007
Drug	furosemide-high intensification	1	2007
Drug	furosemide-low intensification	1	2007
Drug	furosemide-q12 hour bolus	1	2007
Drug	furosemide 40 mg	1	2019
Drug	furosemide 60 mg	1	2010
Drug	furosemide infusion	1	2011
Drug	furosemide injection solution (scp-101)	1	2015
Drug	furosemide injection solution, usp	1	2015
Drug	furosemide)	1	2015
Drug	furosemide/hypertonic saline solution	1	2009
Drug	furosemide/phone contact	1	2014
Drug	fursemide injection solution for subcutaneous administration (80 mg)	1	2014
Other	gadobutrol	1	2014
Drug	gadolinium dota meglumine	1	2016
Drug	gdmt	1	2019
Device	gds accucinch system	1	2014
Drug	ge-145	1	2010
Behavioral	generic dietary feedback from	1	2012
Other	genotyping	1	2010
Behavioral	gentle stretching/education	1	2020
Other	geriatric intervention	1	2018
Drug	ggf2	1	2013
Drug	gik	1	2004
Drug	glial growth factor 2	1	2010
Drug	glial growth factor 2/ neuregulin 1î²3	1	2010
Drug	glimepiride	1	2011
Drug	glp-1	1	2005
Drug	glucagon-like peptide 1	1	2014
Drug	glucocorticoid	1	2009
Other	glucose tolerance test	1	2012
Drug	glutamate infusion	1	2015
Drug	glutamine	1	2012
Drug	glutamine/fish oil supplementation	1	2012
Drug	glycopyrrolate	1	2015
Drug	goal-directed preload	1	2007
Drug	goal-directed preload/afterload decrement	1	2007
Behavioral	goals of care	1	2014
Device	gore-tex dualmesh emerge	1	2016
Device	gore-tex dualmesh emerge/biomaterial	1	2016
Behavioral	gp’s treating hf according the dutch guidelines	1	2012
Drug	granulocyte-colony stimulating factor	1	2008
Drug	grape seed extract (meganatural bp, polyphenolics, inc.)	1	2010
Behavioral	group-based skill building self-care program	1	2013
Behavioral	group i: video training	1	2005
Behavioral	group ii: video training	1	2005
Behavioral	group ii: video training / enhanced self-efficacy (se)	1	2005
Behavioral	group iii: in-person training	1	2005
Behavioral	group iii: in-person training / enhanced se	1	2005
Behavioral	group iv: in-person training	1	2005
Behavioral	group iv: in-person training / enhanced se / support	1	2005
Behavioral	group medical visits	1	2015
Drug	growth hormone	1	2007
Drug	growth hormone releasing hormone	1	2008
Drug	growth hormone releasing hormone/ placebo	1	2008
Drug	gsk2798745	1	2015
Drug	gsk2798745 capsule	1	2014
Drug	gsk2798745 micronized api with sls	1	2016
Drug	gsk2798745 micronized api with sls/hypermellose (tablet b)	1	2016
Drug	gsk2798745 micronized api without sls	1	2016
Drug	gsk2798745 micronized api without sls/hypermellose (tablet a)	1	2016
Drug	gsk2798745 milled api without sls	1	2016
Drug	gsk2798745 milled api without sls/hypermellose (tablet c)	1	2016
Drug	gsk2798745 solution	1	2014
Drug	gsk2798745 suspension	1	2014
Drug	gsk716155	1	2010
Behavioral	gtelephone-administered cognitive-behavioral therapy (t-cbt)	1	2001
Behavioral	guided-hf	1	2015
Other	guideline-directed medical therapy	1	2018
Other	guideline directed heart failure medication	1	2017
Other	guideline directed therapy	1	2017
Other	handled echocardiography in home monitoring program	1	2011
Device	harmony system	1	2015
Drug	hartmann’s solution	1	2013
Device	health buddy system	1	2007
Other	health coaching/home exercise	1	2014
Other	health education intervention	1	2019
Behavioral	health education/independent walking	1	2010
Behavioral	health literacy-tailored education	1	2007
Behavioral	healthy lifestyle	1	2013
Behavioral	healthy lifestyle/sleep education	1	2013
Other	heart-failure related pharmaceutical intervention	1	2014
Behavioral	heart camp (hc) intervention group	1	2012
Behavioral	heart camp group	1	2012
Behavioral	heart care self tracker	1	2009
Other	heart failure application	1	2017
Other	heart failure disease management program	1	2013
Other	heart failure diuretic decision support tool for patient self managementâ©	1	2013
Behavioral	heart failure education/management app	1	2017
Behavioral	heart failure group clinic appointments	1	2007
Other	heart failure guidelines	1	2016
Behavioral	heart failure literature	1	2017
Device	heart failure remote patient monitoring system	1	2008
Other	heart failure risk status diagnostic	1	2011
Other	heart failure self-care education	1	2009
Behavioral	heart failure self-management education	1	2016
Behavioral	heart failure self care support	1	2010
Other	heart failure usual care	1	2013
Behavioral	heart pact program	1	2005
Device	heart rate setting	1	2006
Other	heart rehabilitation	1	2016
Behavioral	heart self care tracker	1	2009
Device	heartlogic off	1	2017
Device	heartlogic on	1	2017
Device	heartman system	1	2018
Other	heartmapp	1	2019
Other	heartmapp/ct	1	2019
Device	heartmate 3	1	2010
Device	heartmate ii	1	2012
Device	heartmate ii (hmii)	1	2016
Device	heartmate ii lvas	1	2014
Device	heartware hvad	1	2014
Device	heartware mvadâ® system	1	2013
Device	heartwareâ® vas (hvad)	1	2013
Other	hed pet	1	2014
Device	hemodynamic group	1	2014
Behavioral	hf dm self care	1	2012
Device	hf pressure measurement system	1	2007
Other	hf training	1	2010
Drug	hf treatment according to swedish guidelines	1	2006
Drug	high-dose loop diuretics	1	2013
Other	high-intensity imt / aerobic/resistance exercise	1	2017
Behavioral	high-intensity imt/walking	1	2012
Behavioral	high-tech	1	2018
Behavioral	high-touch	1	2018
Drug	high dose bisoprolol	1	2010
Biological	high dose trivalent influenza vaccine	1	2016
Drug	high epa	1	2014
Other	high fat	1	2014
Other	high fat/low carbohydrate diet	1	2014
Device	high flow nasal oxygen	1	2018
Other	high intensity care	1	2018
Behavioral	high intensity exercise	1	2014
Behavioral	high intensity exercise training	1	2005
Other	high intensity interval training (hiit)	1	2013
Other	high potassium diet	1	2017
Other	high spo2	1	2015
Other	his-ventricular (hv) optimisation	1	2016
Behavioral	hitcm	1	2007
Behavioral	hitcm only	1	2007
Behavioral	hitcm/cp	1	2007
Device	hm iii	1	2015
Behavioral	home-based cardiac rehabilitation	1	2016
Other	home-based disease management	1	2011
Other	home-based exercise	1	2010
Procedure	home-based hospitalization	1	2017
Other	home-based telerehabilitation	1	2015
Device	home-based tool	1	2018
Procedure	home care telemedicine	1	2005
Other	home exercise	1	2014
Other	home hospitalization	1	2016
Device	home monitoring	1	2015
Device	home telemonitoring	1	2018
Procedure	home telemonitoring of patients with chf	1	2012
Device	home telemonitoring system	1	2020
Other	home telemonitoring system (hts)	1	2019
Radiation	home x-rays	1	2010
Behavioral	homewalking exercise program	1	2001
Behavioral	homing in on health	1	2005
Device	hommed telemonitoring system	1	2006
Device	honeywell hommed telemonitor	1	2011
Drug	hormone replacement therapy	1	2002
Other	hospital-community-family-care management platform online	1	2013
Biological	hpsc-cm therapy	1	2018
Procedure	human cardiac stem cells	1	2009
Biological	human embryonic stem cell-derived cd15	1	2013
Biological	human embryonic stem cell-derived cd15/ isl-1/ progenitors	1	2013
Drug	human recombinant growth hormone	1	2005
Dietary Supplement	hvmn ketone ester	1	2020
Drug	hydralazine isosorbide dinitrate	1	2018
Drug	hydralazine/amlodipine	1	2010
Dietary Supplement	hypercaloric beverages	1	2015
Drug	hypermellose (tablet a)	1	2016
Drug	hypermellose (tablet b)	1	2016
Drug	hypermellose (tablet c)	1	2016
Drug	hypertonic saline solution	1	2009
Other	hyperventilation test	1	2018
Other	hypoxia air	1	2018
Drug	i-123-mibg	1	2015
Device	î¼cor	1	2019
Device	iasd	1	2013
Device	iasd implant	1	2017
Device	iasd system	1	2012
Device	iasd system ii implant	1	2017
Drug	icatibant	1	2019
Behavioral	icd decision aid toolkit	1	2013
Device	icd/crt-d	1	2010
Device	icd/crt-d with home monitoring feature activated	1	2007
Device	icd/crt-d with home monitoring feature deactivated	1	2007
Device	icd/crt implant	1	2008
Behavioral	icdm	1	2011
Drug	iepo	1	2017
Device	ihm in combination with single chamber icd (chronicle icd)	1	2006
Device	ik-5001	1	2010
Behavioral	illness management	1	2011
Behavioral	illness management only	1	2011
Drug	iloprost	1	2018
Other	image fusion of spect mpi	1	2017
Other	image fusion of spect mpi/fluoroscopy venography	1	2017
Procedure	image guided cardiac resynchronization therapy (crt) device lead placement.	1	2011
Other	imaging guided lv lead positioning	1	2011
Other	imaging guided optimal lv lead placement	1	2011
Device	impedance measurement system	1	2017
Device	impedance monitoring feature	1	2009
Device	implant of investigational device system	1	2011
Device	implant of pressure sensor.	1	2008
Device	implant of the hw005 ventricular assist system.	1	2014
Device	implant of the invicta lead	1	2018
Device	implantable cardiac resynchronisation (pacing) device	1	2005
Device	implantable cardioverter defibrillator (icd)	1	2005
Device	implantable cardioverter defibrillator (icd) with crt	1	2005
Device	implantable defibrillator (icd)	1	2005
Device	implantable device: monitoring of intrathoracic impedance using the optivol diagnostic tool.	1	2005
Device	implantable hemodynamic monitor (chronicleâ® ihm),	1	2006
Device	implantable hemodynamic monitor (chronicleâ® ihm),/ihm in combination with single chamber icd (chronicle icd)	1	2006
Device	implantable pulse generators	1	2006
Procedure	implantation	1	2007
Device	implantation of a cardiac resynchronisation therapy (crt) pacing device with	1	2017
Device	implantation of a cardiac resynchronisation therapy (crt) pacing device with/without implanted cardioverter defibrillator	1	2017
Procedure	implantation of a his-pacing lead	1	2018
Procedure	implantation of a lv-pacing lead	1	2018
Device	implantation of the v-wave inter-atrial shunt	1	2013
Procedure	implantation/activation of the vagus nerve stimulator	1	2007
Other	improved primary care hf diagnostics	1	2020
Other	imt	1	2015
Other	in-clinic check-ups	1	2012
Other	in-person primary care clinical follow-up visit	1	2018
Procedure	inactive cross over	1	2012
Drug	increased intravenous bolus loop diuretic dose (bumetanide	1	2015
Drug	increased intravenous bolus loop diuretic dose (bumetanide/furosemide)	1	2015
Behavioral	increasing daily unsaturated fatty acid consumption	1	2017
Device	incremental pump speed of cf-lvad.	1	2012
Drug	incretin effect	1	2017
Drug	indacaterol	1	2015
Drug	indacaterol fumarate	1	2013
Behavioral	independent walking	1	2010
Other	index group	1	2010
Biological	influenza vaccine	1	2014
Biological	influenza virus vaccine (influvac	1	2009
Biological	influenza virus vaccine (influvac/vaxigrip)	1	2009
Behavioral	informed assent discussion	1	2016
Biological	infusion of 3-ohb	1	2017
Drug	infusion of autologous mononuclear bone marrow cells	1	2014
placebo	infusion of placebo	1	2017
Drug	inhaled nebulized milrinone	1	2014
Drug	inhaled nitrite	1	2011
Other	initial evaluation	1	2014
Biological	injection of c3bs-cqr-1	1	2012
Procedure	injection procedures.	1	2008
Drug	inl1	1	2019
Other	innovative supported	1	2018
Drug	ino	1	2017
Other	inpatient hospitalization	1	2016
Device	inspiratory muscle endurance training	1	2018
Other	inspiratory muscle exercise	1	2011
Device	inspiratory muscle strength training	1	2018
Behavioral	inspiratory muscle training exercise intervention	1	2018
Other	inspiratory training	1	2018
Drug	inspra (eplerenone)	1	2013
Behavioral	instruction	1	2008
Drug	insulin glargine	1	2008
Other	integrated cardiac rehabilitation	1	2018
Other	integrated care	1	2011
Other	integrated diagnositic system	1	2010
Other	integrated disease management	1	2019
Behavioral	integration of a team based clinical pharmacist	1	2006
Device	intel health guide	1	2010
Behavioral	intensive quality improvement tools	1	2009
Device	inter-atrial shunt device	1	2015
Other	interactive platform with telemonitoring.	1	2012
Behavioral	interactive voice response system	1	2007
Behavioral	interdisciplinary educational program	1	2019
Behavioral	interdisciplinary palliative care	1	2012
Device	intermittent sequntial pnumatic compression leg sleeves	1	2012
Device	internal electrocardioversion	1	2014
Behavioral	interpersonal	1	2006
Behavioral	interpersonal/behavioral psychotherapy	1	2006
Other	interruption of antibiotic treatment due to pct measurement	1	2016
Other	interval exercise training	1	2013
Other	intervention care	1	2009
Behavioral	intervention group	1	2017
Device	intervention using mhealth	1	2015
Other	interventions with heart failure medications	1	2011
Device	interventricular pacing delay optimization by using tissue doppler-derived displacement curves	1	2010
Other	intra-cardiac echocardiography (ice),	1	2017
Other	intra-cardiac echocardiography (ice),/transesophageal echocardiography (tee)	1	2017
Other	intracardiac echo	1	2015
Device	intracardiac impedance measurement algorithm (integrated in crt-d device)	1	2012
Biological	intracoronary administration of the umbilical cord-derived mesenchymal stromal cells	1	2020
Biological	intracoronary infusion of autologous bone marrow-derived cells	1	2012
Procedure	intracoronary infusion of bmc	1	2006
Procedure	intracoronary injection	1	2011
Procedure	intracoronary stem cell therapy	1	2006
Biological	intramyocardial delivery of bone marrow derived mononuclear cells	1	2009
Procedure	intramyocardial injection	1	2011
Procedure	intramyocardial injection of autologous cd133	1	2007
Procedure	intramyocardial injection of autologous cd133/ marrow cells	1	2007
Drug	intrathecal fentanyl	1	2014
Device	intrathoracic impedance measurement	1	2008
Device	intravascular ventricular assist system (ivas)	1	2015
Drug	intravenous furosemide	1	2015
Drug	intravenous loop diuretic	1	2017
Diagnostic Test	invasive catheter-based mapping	1	2020
Device	invasive mapping with carto3 system	1	2011
Device	invasive mapping with carto3 system/non-invasive mapping with cardioinsight atlas ec mapping system	1	2011
Device	investigational linqâ„¢ hf ramware	1	2018
Biological	inxn-4001	1	2017
Drug	iohexol	1	2019
Drug	iron	1	2016
Drug	iron oligosaccharide	1	2007
Drug	iron sucrose	1	2015
Drug	iron sucrose iv	1	2019
Other	ischemic cold static storage	1	2017
Procedure	ischemic exercise training	1	2006
Biological	isl-1	1	2013
Diagnostic Test	isokinetic dynamometer	1	2020
Drug	isoproterenol	1	2015
Drug	isosorbide dinitrate	1	2012
Drug	isosorbide dinitrate / hydralazine	1	2012
Drug	isosorbide mononitrate	1	2014
Drug	isotonic saline infusion	1	2006
Drug	istaroxime	1	2008
Drug	iti-214	1	2017
Drug	itraconazole	1	2019
Drug	iv chlorothiazide	1	2015
Drug	iv diuretic	1	2005
Drug	iv diuretics	1	2016
Drug	iv loop diuretic	1	2006
Drug	ivabradine 5 mg [corlanor]	1	2019
Behavioral	ivr	1	2013
Behavioral	ivr-enhanced care	1	2010
Drug	iw-1973	1	2017
Device	jarvik 2000 vas	1	2012
Drug	jnj-39588146 15 ng	1	2010
Drug	jnj-39588146 15 ng/kg/min	1	2010
Drug	jnj-39588146 30 ng	1	2010
Drug	jnj-39588146 30 ng/kg/min	1	2010
Drug	jnj-39588146 5 ng	1	2010
Drug	jnj-39588146 5 ng/kg/min	1	2010
Drug	jnj-39588146 5, 15,	1	2010
Drug	jnj-39588146 5, 15,/30 ng/kg/min	1	2010
Behavioral	jumpstart intervention	1	2018
Behavioral	justification nudge	1	2018
Device	kaneka liposorber	1	2007
Other	karate rehabilitation	1	2019
Drug	kcentra	1	2017
Drug	kcl	1	2014
Drug	kg	1	2010
Device	kinesio tape	1	2018
Drug	kno3	1	2014
Drug	kno3, potassium nitrate	1	2016
Device	kronos lv-t, lumax hf-t	1	2006
Drug	kuvan	1	2014
Device	kyma device u-cor system	1	2014
Drug	lactated	1	2015
placebo	lcz696 placebo	1	2016
Drug	ldv fdc)	1	2016
Other	lecg first	1	2011
Drug	ledipasvir fixed dose combination(sof	1	2016
Device	left atrial pressure monitoring system	1	2010
Procedure	left cervico-thoracic sympathetic blockade	1	2010
Device	left ventricular assist device	1	1999
Device	left ventricular assist device (heartmate ii)	1	2009
Device	left ventricular assist device (lvad)	1	2015
Device	left ventricular capture management software	1	2005
Other	leg rising	1	2013
Device	less invasive mitral valve repair	1	2005
Other	level 1: (provide site-specifi information)	1	2009
Other	level 2 (provide site-	1	2009
Other	level 2 (provide site-/patient-specific information)	1	2009
Drug	levocarnitine injection	1	2012
placebo	levocarnitine placebo	1	2012
Drug	levosimendan 2.5 mg/ml	1	2017
Drug	levosimendan 2.5 mg/ml injectable solution	1	2018
Other	li-guided therapy	1	2016
Other	life completion/preparation	1	2008
Other	life extension default ad forms	1	2013
Device	lifepod	1	2020
Behavioral	lifestyle counseling	1	2010
Dietary Supplement	lifestyle modification	1	2015
Behavioral	lifestyle modification (diet, exercise,	1	2006
Behavioral	lifestyle modification (diet, exercise,/behavior)	1	2006
Device	lifestyle monitoring system	1	2005
Device	lifevest	1	2016
Other	light weights	1	2014
Drug	lisinopril	1	2006
Drug	lixivaptan	1	2010
Drug	lmi 1195-101	1	2009
Drug	lmwh	1	2018
Other	local strengthening exercises	1	2016
Drug	loop diuretic	1	2013
Drug	losartan 150 mg	1	2004
Drug	losartan 50 mg	1	2004
Drug	low-dose loop diuretics	1	2013
Other	low-epicatechin dark chocolate	1	2012
Other	low-intensity group	1	2014
Other	low-intensity imt / aerobic/resistance exercise	1	2017
Behavioral	low-intensity imt/walking	1	2012
Device	low-level laser therapy	1	2020
Other	low-sodium diet (1500 mg daily)	1	2011
Other	low carbohydrate diet	1	2014
Drug	low dose bisoprolol	1	2010
Device	low electrical myostimulation	1	2011
Other	low intensity exercise	1	2010
Other	low spo2	1	2015
Other	lung	1	2015
Diagnostic Test	lung function test	1	2020
Device	lung impedance-guided therapy	1	2012
Other	lung/subcutaneous ultrasound	1	2015
Other	lus-guided strategy-of-care	1	2017
Combination Product	lus-guided therapy	1	2018
Procedure	lv dp	1	2009
Procedure	lv dp/dt pressure measurement	1	2009
Device	lv endocardial crt	1	2016
Device	lv lead (quartetâ„¢ lead	1	2009
Other	lv lead placement as per standard of care (without echo guidance)	1	2005
Other	lv stimulus intensity	1	2010
Other	lvad decision aid	1	2014
Dietary Supplement	lycopene supplements	1	2012
Drug	macitentan	1	2017
Drug	macitentan 10 mg	1	2018
Drug	magnesium oxide	1	2019
Device	magnetic nerve stimulators	1	2014
Other	magnetic resonance imaging	1	2015
Dietary Supplement	maltodextrin	1	2020
Behavioral	management app	1	2017
Procedure	mapping	1	2019
Procedure	mapping/pacing the his bundle	1	2019
Procedure	marrow cells	1	2007
placebo	matched placebo (capsules)	1	2007
placebo	matching placebo	1	2018
placebo	matching placebo enalapril	1	2016
placebo	matching placebo patch	1	2009
placebo	matching placebo sacubitril	1	2016
Drug	matching placebo sacubitril/valsartan (lcz696)	1	2016
Behavioral	mawds data entry on app	1	2017
Diagnostic Test	maximal functional capacity by cardiopulmonary exercise testing	1	2019
Behavioral	mayoexpertadvisor	1	2016
Drug	mcc-135	1	2002
Behavioral	mct	1	2016
Procedure	measure of left ventricular	1	2012
Procedure	measure of left ventricular/diastolic pressure at exercise	1	2012
Drug	mecasermin	1	2011
Other	mechanical ventilation video.	1	2013
Procedure	med	1	2001
Other	medical evaluation	1	2018
Diagnostic Test	medical imaging	1	2019
Other	medical management of tricuspid regurgitation	1	2018
Drug	medical therapy	1	2019
Drug	medical ventricular rate control	1	2012
Behavioral	medication adherence telemonitoring	1	2015
Other	medication education tool	1	2006
Drug	medication management	1	2018
Drug	medication suspension (dms)	1	2017
Drug	medication to control ventricular rate in af	1	2009
Device	mediguideâ„¢	1	2012
Behavioral	meds to beds	1	2018
Device	medtronic 4196 lead	1	2018
Device	medtronic icd with opti vol-monitor	1	2019
Device	medtronic primeadvanced neurostimulator	1	2010
Drug	melatonin 10 mg	1	2019
Behavioral	memory training	1	2016
Biological	mesenchymal precursor cells (mpcs)	1	2008
Biological	mesenchymal stem cell transplantation	1	2015
Biological	mesenchymal stem cells (msc)	1	2015
Biological	mesenchymal stromal cell	1	2008
Other	metabolic substrate modulation	1	2010
Drug	metformini hydrochloridum (siofor 1000 tbl, berlin)	1	2012
Other	methodology	1	2017
Drug	methotrexate	1	2008
Drug	methylprednisolone	1	2017
Drug	metolazone 5 mg	1	2016
Drug	metolazone 5 mg / iv diuretics	1	2016
Drug	metolazone oral tablet	1	2018
Drug	metoprolol xr	1	2019
Behavioral	mi	1	2013
Behavioral	mi-based educational control condition	1	2017
Behavioral	mi / ivr	1	2013
Genetic	microarray analysis	1	2011
Drug	micronutrients	1	2011
Drug	midazolam	1	2013
Drug	milrinone	1	2013
Drug	milrinone 10mg er	1	2013
Drug	milrinone 14mg	1	2013
Drug	milrinone 6mg	1	2013
Drug	min	1	2010
Behavioral	mindful steps	1	2016
Behavioral	mindfulness training (mt)	1	2018
Device	minimal extracorporeal circulation (mec)	1	2016
Behavioral	minnesota living heart failure questionnaire (mlhf)	1	2014
Device	mio slice	1	2019
Drug	mirabegron	1	2017
Dietary Supplement	mitoq	1	2019
Device	mitraclip	1	2019
Device	mitraclip system	1	2012
Device	mitral valve repair	1	2017
Drug	ml inj 15ml	1	2017
Drug	ml injectable solution	1	2018
Other	mobile health technology platform	1	2019
Device	mobile phone app (vad care app)	1	2017
Procedure	mobile team	1	2007
Other	moderate-intensity group	1	2014
Behavioral	moderate continuous exercise	1	2014
Other	moderate intensity continuous exercise training	1	2013
Behavioral	moderate intensity continuous training	1	2017
Other	monthly review arm	1	2009
Behavioral	motivational interviewing tailored intervention	1	2014
Behavioral	motivational support only	1	2013
Drug	moxifloxacin	1	2018
Drug	moxifloxacin 400 mg	1	2018
Device	mpp	1	2013
Device	mpp on	1	2015
Drug	mtp-131	1	2015
Behavioral	multi-domain rehabilitation intervention	1	2014
Other	multi-professional breathlessness service (mbs)	1	2015
Other	multicomponent treatment	1	2005
Behavioral	multidisciplinary palliative care team met with patient	1	2006
Other	multifaceted strategy based on sending text messages(sms)	1	2019
Other	multilevel guided discharge planning	1	2018
Device	multipoint pacing	1	2013
Device	multipole pacing	1	2017
Device	multispot sequential lv-ventricular pacing (multispot-seq)	1	2016
Device	multispot simultaneous lv-ventricular pacing (multispot-syn)	1	2016
Drug	muscle contraction with metabolite solution administration	1	2013
Genetic	mydicar phase 1 (open-label, serial dose-escalation study)	1	2007
placebo	mydicar phase 2 (placebo-controlled, randomized study)	1	2007
Other	myia healthâ® remote patient monitoring unblinded treatment arm	1	2020
Drug	myk-491	1	2018
Other	myocardial perfusion scintigraphy	1	2015
Radiation	myocardial scintigraphy	1	2015
Drug	n-3 pufa	1	2006
Drug	n-3 pufas	1	2010
Drug	nacl 0,9%	1	2007
Drug	nacl 7,5% (hypertonic saline solution)	1	2007
Behavioral	narrative intervention	1	2019
Drug	natrecor (nesiritide)	1	2005
placebo	natrecor, a recombinant form of b-type natriuretic peptide, made by scios, inc. vs. placebo	1	2005
Device	navh	1	2016
Drug	nebulized sodium nitrite	1	2016
Drug	neprilysin	1	2017
Drug	neseritide	1	2006
Drug	nesiritide (1	1	2007
Drug	nesiritide (1/0.01)	1	2007
Drug	nesiritide (2	1	2007
Drug	nesiritide (2/0.005)	1	2007
Drug	nesiritide (natrecor(tm))	1	2005
Drug	nesiritide, furosemide	1	2008
Drug	nesritide (2	1	2007
Drug	nesritide (2/0.01)	1	2007
Dietary Supplement	nestlã© noir intense 40 grx2	1	2007
placebo	nestlã© placebo chocolate 40 grx2	1	2007
Device	neurally adjusted ventilatory assist (nava) provided by a commercially available mechanical ventilator (servo i, maquet critical care, solna, sweden).	1	2008
Drug	neuregulin 1î²3	1	2010
Device	neuromuscular electrical stimulation (nmes)	1	2018
Device	neuromuscular electrical stimulator	1	2016
Device	neurotronik cans therapy system	1	2016
Device	neurotronik cans therapyâ„¢ system	1	2017
Device	neurotronik cans therapyâ® system	1	2018
Device	new living chf	1	2008
Procedure	new model of ambulatory care with use of of non-invasive vital signs assessment	1	2018
Procedure	new model of ambulatory care with use of of non-invasive vital signs assessment/telemedicine	1	2018
Diagnostic Test	new york heart association class i	1	2018
Diagnostic Test	new york heart association class ii-iv	1	2018
Drug	ng-monomethyl-l-arginine (drug)	1	2006
Other	nhgdoc domain heart failure	1	2012
Other	nicas guided crt optimization	1	2014
Device	nicas system	1	2013
Drug	nicorandil	1	2009
Device	nintendo wii fit	1	2019
Dietary Supplement	nitrate-free beetroot juice	1	2018
Dietary Supplement	nitrate depleted beetroot juice	1	2013
Dietary Supplement	nitrate rich beetroot juice	1	2013
Dietary Supplement	nitrate supplementation	1	2015
Drug	nitrates	1	2017
Drug	nitrite	1	2013
Drug	nitrogen	1	2003
Drug	nitroglycerin (ntg)	1	2017
Other	no-crt	1	2011
Other	no additional treatment	1	2007
Other	no hf training	1	2010
Device	no home monitoring	1	2015
Behavioral	no intervention–usual care	1	2017
Other	no intervention: optimal medical therapy	1	2011
Behavioral	no intervervention usual care	1	2017
Device	nocturnal oxygen	1	2010
Device	nocturnal oxygen treatment from oxygen concentrators	1	2006
Device	nocturnal supplemental oxygen	1	2013
Drug	non-arb	1	2005
Diagnostic Test	non-invasive body surface mapping	1	2020
Other	non-invasive haemodynamic optimisation	1	2010
Device	non-invasive mapping with cardioinsight atlas ec mapping system	1	2011
Device	non-invasive ventilation	1	2018
Other	non-ischemic preservation	1	2017
Device	non invasive ventilation (niv)	1	2017
Procedure	noninvasive electrical dyssynchrony study	1	2017
Device	noninvasive ventilation (bi-pap)	1	2017
Device	noninvasive ventilation (cpap)	1	2017
Other	noninvasive ventilatory support	1	2015
Behavioral	nordic walking	1	2014
Diagnostic Test	norepinephrine	1	2018
Other	normal rv pacing	1	2005
Drug	normal saline (0.9%)	1	2007
Other	normal saline 0.9%	1	2016
Other	notices	1	2009
Diagnostic Test	nt-pro bnp	1	2018
Other	nt-probnp (cardiac biomarkers)	1	2016
Other	nt-probnp guided discharge	1	2011
Other	nt-probnp guided hf therapy	1	2006
Device	nt-probnp measurements	1	2005
Procedure	nt-probnp testing	1	2006
Other	nurse-based care	1	2017
Behavioral	nurse-led group clinic visits	1	2007
Behavioral	nurse-management	1	2005
Drug	nurse management	1	2006
Procedure	nurse monitored heart failure program	1	2012
Dietary Supplement	nutridrink	1	2008
Other	nutrition education	1	2019
Other	nutritional	1	2020
Behavioral	nutritional education	1	2009
Dietary Supplement	nutritional supplementation	1	2020
Dietary Supplement	nutritional supplementation/pulmonary rehabilitation	1	2020
Other	nutritional support	1	2018
Other	nutritional/dietary manipulation	1	2020
Device	nxstage system one	1	2006
Diagnostic Test	nyha assessment	1	2019
Device	occlutech afr device	1	2017
Behavioral	older drivers website	1	2019
Drug	olmesartan medoxomil	1	2006
Dietary Supplement	omacor	1	2005
Dietary Supplement	omega 3	1	2012
Dietary Supplement	omega 3/lycopene supplements	1	2012
Dietary Supplement	omga3	1	2010
Other	omm, optimal medical management	1	2015
Other	on-demand audio messages of heart failure education themes	1	2016
Drug	opc-41061 （tolvaptan)	1	2007
Drug	opc-61815	1	2018
Drug	opc-61815 16mg	1	2018
Drug	opc-61815 32mg	1	2018
Drug	opc-61815 injection 16 mg	1	2019
Drug	opc-61815 injection 16mg	1	2017
Drug	opc-61815 injection 2mg	1	2017
Drug	opc-61815 injection 4mg	1	2017
Drug	opc-61815 injection 8 mg	1	2019
Drug	opc-61815 injection 8mg	1	2017
Behavioral	opinion leader generated	1	2005
Behavioral	opinion leader generated/endorsed evidence summaries	1	2005
Other	opt out approach for ahcah liaison visit	1	2018
Device	optilogg	1	2018
Behavioral	optimal discharge planning	1	2018
Biological	optimal heart failure therapy	1	2016
Other	optimal medical treatment	1	2007
Other	optimisation of v-v timing using r wave on surface ecg	1	2014
Device	optimisation of vv delay	1	2010
Other	optimised heart failure management	1	2013
Diagnostic Test	optimization of crt device	1	2017
Device	optimization using echocardiography	1	2010
Other	optimized echo-guided crt pacing	1	2005
Device	optimized interventricular delay biventricular pacing	1	2007
Device	optimizer smart	1	2017
Device	optimizer smart system	1	2017
Device	optimizer smart system with 2-leads	1	2017
Procedure	optimizing myocardial lead placement for cardiac resynchronization therapy (crt) devices	1	2011
Behavioral	optimizing processes of care	1	2006
Drug	optimizing therapeutic treatments	1	2006
Other	or crt	1	2013
Other	or handout	1	2017
Dietary Supplement	oral 3-hydroxybutyrate salts	1	2019
Drug	oral furosemide tablets (80 mg)	1	2014
Drug	oral myeloperoxidase inhibitor	1	2018
Dietary Supplement	oral nutrition supplement, food for special medical purposes	1	2009
Drug	oral r,r’-fenoterol	1	2011
Drug	oral racemic fenoterol	1	2011
Dietary Supplement	oral sodium chloride	1	2020
Drug	oral sodium nitrite	1	2016
Device	organ care system	1	2009
Procedure	organ perfusion for heart transplantation	1	2015
Procedure	orthostatic test	1	2015
Procedure	outpatient clinic follow-up	1	2006
Device	oxycon mobile	1	2019
Procedure	oxygen application	1	2019
Drug	oxypurinol	1	2003
Device	p-ecm implant	1	2014
Procedure	pace make active	1	2012
Procedure	pace make active/inactive cross over	1	2012
Device	pacemaker medtronic enrhythm	1	2005
Device	pacemaker system will be implanted but set to pacing off.	1	2014
Device	pacemaker: av optimised, his pacing.	1	2016
Device	pacing lead (model 4296 lv lead)	1	2009
Procedure	pacing the his bundle	1	2019
Other	pact-hf model	1	2014
Behavioral	palliative care	1	2011
Other	palliative care consultation	1	2012
Other	palliative care intervention	1	2014
Procedure	papillary muscle approximation	1	2017
Drug	para-aminohippurate	1	2019
Device	paradym crt	1	2009
Device	paradym crt / physiological diagnosis (phd)	1	2009
Device	paradym crt 8770	1	2014
Device	paradym rf sonr	1	2011
Other	passive leg cycle exercise with stretching	1	2008
Other	passive leg cycle exercise with stretching/resistance training	1	2008
Behavioral	patch intervention	1	2013
Behavioral	patient	1	2005
Behavioral	patient-centered advance care planning	1	2005
Other	patient-specific information)	1	2009
Device	patient advisory module	1	2010
Behavioral	patient engagement materials	1	2017
Behavioral	patient heart failure mtm intervention	1	2018
Other	patient navigator	1	2012
Behavioral	patient/family education	1	2005
Drug	pb1046 injection	1	2016
Drug	pde-v	1	2009
Procedure	peep decremental	1	2015
Procedure	peep incremental	1	2015
Procedure	percutaneous coronary intervention	1	2013
Procedure	percutaneous intracoronary injection	1	2008
Procedure	percutaneous intramyocardial injection	1	2008
Device	percutaneous ventricular restoration using heartechâ® device	1	2019
Behavioral	performance of wheels-i in promoting dash	1	2017
Behavioral	performance of wheels-i in promoting dash/srd adoption	1	2017
Procedure	pericardiotomy	1	2019
Other	period of cardiac rehabilitation	1	2014
Drug	peritoneal dialysis (pd)	1	2012
Behavioral	person-centred care at distance	1	2017
Device	personalised programming	1	2018
Device	personalised rate-response settings	1	2016
Device	pet scan	1	1999
Behavioral	pharmaceutical counseling	1	2015
Other	pharmacist discharge medication services	1	2016
Behavioral	pharmacist heart failure mtm training	1	2018
Behavioral	pharmacist intervention	1	2006
Other	pharmacogenomic studies	1	2011
Other	pharmacogenomic study	1	2016
Other	pharmacological study	1	2016
Drug	phenylephrine	1	2007
Drug	phone contact	1	2014
Other	phr messaging	1	2016
Procedure	phrenic nerve stimulation	1	2007
Behavioral	physical activity group	1	2016
Other	physical therapy session	1	2016
Behavioral	physical training	1	2018
Device	physiological diagnosis (phd)	1	2009
Drug	piboserod	1	2007
Drug	pirfenidone	1	2016
Drug	pitavastatin	1	2008
placebo	placebo (10 mg)	1	2014
placebo	placebo (dextrose)	1	2012
placebo	placebo (for polysaccharide iron complex)	1	2014
placebo	placebo (gummeline)	1	2013
placebo	placebo (normal saline)	1	2017
placebo	placebo (plasmalyte a)	1	2015
placebo	placebo (saline)	1	2011
placebo	placebo (treatment 1)	1	2013
placebo	placebo (whey protein)	1	2018
placebo	placebo bay 1753011	1	2019
placebo	placebo capsule	1	2014
placebo	placebo capsules	1	2017
placebo	placebo comparator: sugar pill	1	2012
placebo	placebo electrical stimulation	1	2013
placebo	placebo for aliskiren	1	2010
placebo	placebo for allopurinol	1	2020
placebo	placebo for cxl-1020 cohort 1	1	2010
placebo	placebo for cxl-1020 cohort 2	1	2010
placebo	placebo for vericiguat	1	2016
placebo	placebo for verinurad	1	2020
placebo	placebo furosemide	1	2019
placebo	placebo group	1	2014
placebo	placebo injection	1	2016
placebo	placebo of lcz696 (sacubitril	1	2016
Drug	placebo of lcz696 (sacubitril/valsartan)	1	2016
placebo	placebo of tolvaptan	1	2011
placebo	placebo of valsartan	1	2016
placebo	placebo of vildagliptin	1	2009
placebo	placebo phototherapy	1	2017
placebo	placebo pills	1	2017
placebo	placebo powder	1	2017
placebo	placebo suspension	1	2014
placebo	placebo tablet	1	2010
placebo	placebo to aliskiren	1	2009
placebo	placebo to empagliflozin	1	2019
placebo	placebo to enalapril	1	2015
placebo	placebo to lcz696	1	2015
placebo	placebo to match enalapril	1	2017
placebo	placebo to match sacubitril	1	2017
Drug	placebo to match sacubitril/valsartan	1	2017
placebo	placebo to match saxagliptin	1	2016
placebo	placebo to match sitagliptin	1	2016
placebo	placebo to match valsartan	1	2017
placebo	placebo to ramipril	1	2009
placebo	placebo to sacubitril	1	2017
Drug	placebo to sacubitril/valsartan	1	2017
placebo	placebo to valsartan	1	2017
placebo	placebo,	1	2006
Biological	placebo/control arm	1	2016
Drug	placebo/sugar pill	1	2012
Drug	placebo/torasemide	1	2015
Procedure	placing a guidewire in coronary sinus for measurement of q-lv during his bundle pacing or, if needed, for lv pacing	1	2019
Drug	platelet inhibitors	1	2000
Other	polygraphy	1	2014
Other	polygraphy/ecg	1	2014
Genetic	polymerase chain reaction	1	2011
Genetic	polymorphism analysis	1	2011
Drug	polysaccharide iron complex 150 mg	1	2014
Other	pop up interruption alert	1	2016
Other	positive psychology	1	2011
Other	post-stroke rehabilitation program	1	2015
Drug	potassium chloride (kcl)	1	2016
Drug	potassium nitrate (kno3)	1	2016
Device	powerbreathe (breathing muscle training)	1	2019
Behavioral	prado-ic	1	2017
Drug	prasugrel 10 mg daily x 2 weeks	1	2012
Drug	pravastatin	1	2008
Procedure	pre-discharge nt-probnp based treatment	1	2007
Other	pre-procedure speckle-tracking echocardiography	1	2013
Device	precardia system	1	2019
Device	precision spinal cord stimulator system	1	2016
Other	preoperative colloid fluid bolus (gelofusine)	1	2018
Diagnostic Test	preoperative transthoracic echocardiography	1	2018
Other	preparation/life completion	1	2012
Drug	preset increase in frusemide dose	1	2011
Other	preticard patient care management	1	2016
Procedure	primary epicardial placement of left ventricular lead	1	2011
Behavioral	primary palliative care	1	2017
Behavioral	private feedback	1	2018
Drug	probenecid 1 gr oral twice daily	1	2013
Dietary Supplement	probiotic	1	2018
Behavioral	problem-solving treatment	1	2017
Other	problem solving therapy	1	2019
Biological	progenitors	1	2013
Other	programmer ecg first	1	2011
Other	programming optimization by qrs	1	2011
Other	progressive interval training	1	2019
Device	promote qâ® device system)	1	2009
Other	prompting	1	2019
Drug	prostacyclin	1	2012
Other	protocolized diuretic therapy	1	2020
Procedure	provider education, computer reminders, nurse case management	1	2001
Behavioral	psycho-behavioral intervention	1	2017
Behavioral	psychoeducational	1	2008
Behavioral	psychoeducational intervention by group (sg)	1	2005
Behavioral	psychoeducational telephone counseling (tc)	1	2005
Behavioral	psychospiritual	1	2011
Procedure	ptca	1	2000
Procedure	ptca/stents	1	2000
Other	ptco2	1	2018
Device	ptma implant	1	2007
Behavioral	publicly released hospital cardiac report cards	1	2005
Procedure	pulmonary arterial denervation	1	2014
Dietary Supplement	pulmonary rehabilitation	1	2020
Procedure	pulse rate control	1	2014
Other	pulse wave velocity	1	2012
Drug	pyridostigmine bromide	1	2011
Drug	qishenyiqi dropping pills	1	2019
Procedure	qlv interval measurement	1	2014
Device	quad group	1	2011
Device	quadripolar lv lead (pacing configurations)	1	2009
Behavioral	qualitative interview	1	2016
Behavioral	qualitative interview/adherence measurements	1	2016
Other	quality iq patient simulations	1	2019
Other	quality of life assessment	1	2018
Other	quality of life questionnaire	1	2015
Other	quality of life questionnaire.	1	2018
Diagnostic Test	quantitated blood volume analysis	1	2019
Other	quarterly in clinic follow ups	1	2010
Other	quarterly in clinic follow ups/remote monitoring	1	2010
Other	quarterly remote follow ups	1	2010
Other	quarterly remote follow ups / additional phone calls/remote monitoring	1	2010
Other	quarterly remote follow ups/remote monitoring	1	2010
Other	quarterly review arm	1	2009
Device	quartet 1457q lv lead	1	2015
Behavioral	question	1	2018
Behavioral	question/topic prompt list	1	2018
Device	quickflex micro model 1258t left heart lead	1	2008
Device	quickopt	1	2009
Drug	raas blockers	1	2014
Drug	radioisotope	1	2014
Device	rate adaptive atrial pacing using a dual-chamber pacemaker	1	2014
Other	rate control	1	2011
Other	rate vs rhythm control strategies for atrial fibrillation	1	2008
Other	rate vs rhythm control strategies in atrial fibrillation	1	2008
Dietary Supplement	re	1	2014
Dietary Supplement	re/bcaa supplementation	1	2014
Other	received routine treatment	1	2018
Behavioral	recollection	1	2011
Drug	recombinant b-type, natriuretic peptide	1	2007
Behavioral	recommendation of regular moderate exercise	1	2009
Device	recording doppler ultrasound signals noninvasively	1	2014
Other	recording of daily activity using wristwatch accelerometers.	1	2013
Other	recording of lvad data during routine visits	1	2013
Other	recording of lvad data during routine visits/daily life.	1	2013
Other	recoverlink technology	1	2016
Device	reds-guided	1	2018
Behavioral	reducing sedentary behavior	1	2016
Other	reference position	1	2013
Other	referral to mtm pharmacist	1	2019
Drug	regadenoson	1	2015
Drug	regional nerve block with a local anesthetic (lidocaine)	1	2016
Behavioral	regular attention	1	2018
Other	regular diet	1	2016
Drug	regular management	1	2017
Drug	regular management/levosimendan	1	2017
Behavioral	regular, pharmacy based intervention	1	2012
Behavioral	rehabilitation intervention	1	2011
Other	reinforced multidisciplinary follow-up	1	2019
Behavioral	relaxation response	1	2011
Behavioral	relaxation technique	1	2001
Other	remote ischemic conditioning (using sphygmomanometer)	1	2014
Other	remote ischemic preconditioning	1	2009
Other	remote monitoring	1	2010
Other	remote outpatient monitoring	1	2011
Device	remote patient management	1	2013
Device	remote patient monitoring	1	2012
Device	remote patient monitoring (motiva)	1	2014
Device	remote patient monitoring (partnership for the heart)	1	2007
Procedure	renal artery denervation	1	2011
Device	renal denervation	1	2014
Device	renal denervation with enlightn st. jude medical	1	2012
Device	renal denervation with paradise recor	1	2012
Device	renal denervation with symplicity flex medtronic	1	2012
Device	renal denervation with symplicity flex medtronic/ardian	1	2012
Device	renal denervation with v2 vessix	1	2012
Device	renal sympathetic denervation	1	2013
Procedure	renal sympathetic modification	1	2011
Device	renewal tr2	1	2005
Procedure	replacement	1	2018
Other	reports	1	2009
Other	reports/notices	1	2009
Device	reprieve cardiovascular system	1	2019
Device	reprogramming of crt device settings to optimal electrical synchrony	1	2019
Behavioral	resistance band	1	2012
Other	resistance exercise training	1	2015
Other	resistance physical training program	1	2015
Behavioral	respecting choices first steps	1	2018
Other	reveal linq icm cardiac monitor, taped on the subject’s chest rather than inserted in the body.	1	2016
Device	reveal xtâ® insertable cardiac monitor	1	2011
Procedure	reversible pulmonary artery banding	1	2016
Device	revivent tc ventricular enhancement system	1	2019
Device	rheos baroreflex activation therapy system	1	2008
Device	rheosâ® system	1	2009
Drug	rhnrg-1	1	2017
Drug	rhnrg-1 dose 1	1	2010
Drug	rhnrg-1 dose 2	1	2010
Procedure	rhythm control	1	2011
Dietary Supplement	rice bran oil capsules	1	2012
Drug	rifaximin	1	2015
Device	right ventricular pacing	1	2009
Other	risk stratification	1	2016
Other	risk stratification/transitional care intervention	1	2016
Drug	rivaroxaban, 10 mg	1	2014
Drug	rivaroxaban, 7.5 mg	1	2014
Drug	rlx030 (serelaxin)	1	2013
Drug	rolofyline	1	2008
Other	room air	1	2018
Other	routine care	1	2012
Other	routine in office visits	1	2010
Drug	ruboxistaurin	1	2016
Device	rv ddd(r)-60	1	2015
Device	rv ddd(r)-60 with av optimization	1	2015
Drug	sacubitril-valsartan	1	2019
Drug	sacubitril - valsartan (formerly lcz696, entrestoâ®)	1	2016
Drug	sacubitril / valsartan oral tablet	1	2018
Drug	sacubitril/valsartan (lcz696) matching placebo	1	2015
Drug	sacubitril/valsatran	1	2017
Other	saline 0.9%	1	2010
Other	saline 0.9%/placebo tablet	1	2010
Drug	saline infusion	1	2015
Drug	saline isotonic solution	1	2011
Drug	saline load	1	2012
placebo	saline placebo for nitrite	1	2013
Drug	saline solution for injection	1	2017
Dietary Supplement	salt	1	2009
Dietary Supplement	salt/fluid restriction	1	2009
Drug	samsca	1	2012
Device	sapien 3 thv	1	2016
Drug	saxagliptin	1	2016
Combination Product	sc2wear furosemide infusor	1	2017
Other	screening	1	2015
Other	screening for pc by means of two different screening tools	1	2019
Other	screening/treatment of comorbidities	1	2015
Other	script	1	2013
Other	script/cpr/mechanical ventilation video.	1	2013
Device	seca medical body composition analyser 515	1	2017
Other	secondary prevention	1	2014
Other	secondary prevention/cardiac rehabilitation clinic	1	2014
Behavioral	see simulation room, usual education	1	2013
Device	seeq	1	2015
Device	selective cytopheretic device	1	2019
Behavioral	self-care behavior	1	2019
Behavioral	self-management	1	2001
Behavioral	self-management- prevention of illness	1	2007
Behavioral	self-management education for heart failure	1	2016
Behavioral	self-management of illness	1	2007
Behavioral	self-regulation programme	1	2020
Behavioral	self assessment score	1	2014
Behavioral	self management education programme	1	2009
Drug	seloken zok	1	2002
Drug	seloken zok/toprol-xl	1	2002
Behavioral	sensor-controlled digital game (scdg)	1	2019
Behavioral	sensor only	1	2019
Device	sequential vv pacing	1	2005
Genetic	serca2a (mydicar)	1	2012
Drug	serelaxin	1	2013
Other	serious illness care program (sicp)	1	2018
Drug	sertraline	1	2004
Procedure	serum nt-probnp concentration	1	2019
Other	sg1002	1	2013
Other	sham comparator	1	2014
Other	sham control	1	2009
Other	sham cpap treatment	1	2013
Device	sham high-intensity imt	1	2012
Other	sham imt	1	2017
Other	sham imt / aerobic/resistance exercise	1	2017
Procedure	sham room air	1	2019
Device	sham tvs	1	2017
Diagnostic Test	sham ultrasound evaluation of the inferior vena cava diameter	1	2017
Biological	sham, no injection	1	2012
Drug	shenfu zhusheye	1	2014
Device	shockwave therapy	1	2018
Other	short stay unit	1	2017
Diagnostic Test	shuttle walk test	1	2017
Other	side bar non interruptive provider checklist	1	2016
Behavioral	sidera^b	1	2019
Other	signs remote monitoring	1	2016
Drug	sildenafil citrate	1	2017
Other	simulation-based mastery learning (sbml)	1	2017
Other	simultaneous determination of paco2	1	2018
Other	simultaneous determination of paco2/ptco2	1	2018
Device	simultaneous vv pacing	1	2005
Behavioral	single illness management	1	2006
Procedure	sinus rhythm control	1	2014
Drug	sitagliptin 100mg	1	2018
Drug	sitaxsentan sodium	1	2006
Other	sitting position	1	2013
Procedure	six minute walk test	1	2014
Drug	sk&f-105517-d 10 mg capsule	1	2008
Drug	sk&f-105517-d 20 mg capsule	1	2008
Drug	sk&f-105517-d 40 mg capsule	1	2008
Behavioral	sleep education	1	2013
Behavioral	sleep monitoring	1	2018
Behavioral	slow breathing	1	2009
Drug	slv320	1	2005
Behavioral	social incentive	1	2017
Behavioral	social network feedback	1	2018
Behavioral	sodium-restricted diet (srd)	1	2009
Drug	sodium bicarbonate	1	2007
Drug	sodium ferric gluconate	1	2013
Drug	sodium nitrite inhalation solution	1	2014
Behavioral	sodium reduction	1	2012
Other	sodium restricted diet	1	2016
Other	sodium restriction	1	2013
Drug	sofosbuvir	1	2016
Drug	sofosbuvir/ledipasvir fixed dose combination(sof/ldv fdc)	1	2016
Device	software beutel tm	1	2008
Drug	soluble epoxide hydrolase	1	2008
Drug	somatropin	1	2020
Device	somnotouch device (somnomedics)	1	2015
Drug	sonazoid	1	2017
Other	sonr	1	2011
Device	sonr automatic optimization feature turned on ("av	1	2015
Device	sonr automatic optimization feature turned on (“av/vv”).	1	2015
Device	sonr crt optimization ‘off’	1	2013
Device	sonr crt optimization ‘on’	1	2013
Drug	sotagliflozin (sar439954)	1	2018
Behavioral	specialized community disease management	1	2014
Device	sphygmocor	1	2007
Device	spinal cord stimulation system	1	2011
Drug	spironolacton	1	2015
Drug	sr121463b	1	2006
Other	srd	1	2014
Behavioral	srd adoption	1	2017
Behavioral	srd intervention vs. control diet on hfpef functional cardiovascular risk factors	1	2017
Other	st2-guided strategy	1	2016
Other	standard	1	2008
Procedure	standard-of-care treatment with mock mapping	1	2008
Procedure	standard-of-care treatment with mock mapping/injection procedures.	1	2008
Other	standard cardiac imaging	1	2010
Device	standard configuration vs. azygos coil	1	2008
Other	standard default ad forms	1	2013
Behavioral	standard dietary sodium education	1	2016
Biological	standard dose quadrivalent influenza vaccine	1	2016
Other	standard management	1	2013
Other	standard of care arm	1	2018
Other	standard of care as vasoactive agent	1	2020
Drug	standard of care diuretic therapy	1	2016
Other	standard of care for heart failure/coronary artery disease	1	2013
Drug	standard of care iv antihypertensive	1	2008
Other	standard of care medical managment therapy for heart failure	1	2012
Other	standard outpatient heart failure management	1	2017
Procedure	standard primary health care	1	2012
Drug	standard therapy for heart failure	1	2011
Drug	standard treatment strategy	1	2013
Other	standard v-v timing settings	1	2014
Behavioral	standardized education sessions	1	2013
Other	standardized heart failure discharge summary to primary care physiciansâ©	1	2013
Drug	starting dpp-4 inhibitor after treatment of heart failure	1	2014
Other	static handgrip	1	2015
Drug	statin	1	2010
Drug	statin therapy	1	2012
Biological	stem cells administered to participants	1	2017
Drug	stem cells infusion	1	2016
Procedure	stents	1	2000
Behavioral	stepped care for depression	1	2016
Drug	stepped pharmacologic care	1	2008
Device	stimulation of the diaphragm	1	2008
Device	stimulette r4x	1	2016
Drug	strata 1 cxl-1020	1	2010
Drug	strata 2 cxl-1020	1	2010
Drug	strata 3 cxl-1020	1	2010
Other	strength	1	2019
Behavioral	strength exercise intervention	1	2018
Behavioral	strength training intervention	1	2005
Other	strength/balance training/nutrition education	1	2019
Diagnostic Test	stress cmr	1	2017
Diagnostic Test	stress echocardiography	1	2017
Other	stretching exercises	1	2016
Behavioral	stretching/flexibility	1	2014
Other	stretching/resistance training	1	2008
Behavioral	structured access to a wii game computer (wii)	1	2013
Other	structured telephone	1	2011
Other	structured telephone / remote outpatient monitoring	1	2011
Other	structured transitional protocol planning post-discharge care	1	2020
Other	subcutaneous ultrasound	1	2015
Other	subjects with chf via conventional clinic visit according to the latest relevant guidelines	1	2013
Diagnostic Test	submã¡ximal functional capacity assesment by 6 minutes walk test	1	2019
Other	submaximal exercise test	1	2015
Drug	substance p	1	2012
Drug	sucrose (3%)	1	2008
Drug	sucrosomial iron	1	2019
Drug	sugammadex	1	2012
Diagnostic Test	supersonic image	1	2019
Behavioral	supervised exercise training program	1	2002
Behavioral	supervised hospital-based exercise training	1	2011
Other	supportive care management programme	1	2020
Procedure	surgical intervention	1	2016
Procedure	surgical placement of jarvik 2015 vad	1	2016
Device	surgical placement of the jarvik 2015 vad	1	2016
Procedure	surgical resection of the greater splanchnic nerve	1	2018
Drug	suspending dpp-4 inhibitor after treatment of heart failure	1	2014
Drug	suspending dpp-4 inhibitor, in outpatient service	1	2014
Procedure	svr	1	2001
Other	swift home intervention	1	2014
Procedure	symptom management service for heart failure	1	2011
Behavioral	symptom questionnaire	1	2015
Behavioral	symptom reporting	1	2011
Drug	symptom treatment	1	2016
Other	symptoms	1	2016
Other	symptoms/signs remote monitoring	1	2016
Device	syncardia 50cc temporary total artificial heart (tah-t)	1	2014
Device	syncav programmed on	1	2019
Behavioral	systemchange	1	2017
Drug	tadalafil	1	2012
Behavioral	tai chi	1	2012
Behavioral	tai chi training	1	2011
Procedure	tailored healthmedia programs on ehr patient portal	1	2005
Behavioral	teach back method of patient discharge teaching	1	2011
Behavioral	teach to goal (ttg)	1	2006
Device	tele-health monitoring	1	2010
Device	tele-monitoring/health coaching	1	2015
Device	telecardiology program	1	2014
Behavioral	telehealth monitoring	1	2006
Device	telehealth self management (tsm)	1	2014
Device	telehomecare	1	2005
Device	telemonitoring assisted self-care	1	2012
Device	telemonitoring devices	1	2019
Procedure	telemonitoring for patients with congestive heart failure	1	2012
Device	telemonitoring in patients with heart failure	1	2007
Device	telemonitoring of weight, pulse	1	2015
Device	telemonitoring of weight, pulse/blood pressure	1	2015
Other	telephone-delivered api	1	2011
Behavioral	telephone-delivered bei	1	2011
Behavioral	telephone-delivered bi	1	2011
Other	telephone call	1	2018
Behavioral	telephone follow-up	1	2015
Other	telephone management	1	2007
Other	telephone management with standard patient education	1	2007
Other	telephone management/a motivational intervention	1	2007
Behavioral	telephone monitoring	1	2019
Procedure	telephone, videophone care	1	2003
Other	telephonic disease management	1	2014
Behavioral	telerehabilitation for patients with a cardiac resynchronisation device	1	2020
Drug	telmisartan	1	2007
Drug	telmisartan, bisoprolol	1	2007
Procedure	temporary pacing study	1	2020
Drug	terbutaline	1	2005
Drug	terbutaline infusion	1	2008
Drug	terbutaline/metoprolol/carvedilol	1	2005
Behavioral	test of general knowledge	1	2015
Device	testing of the autocapture features of the device	1	2008
Drug	testosterone replacement	1	2013
Dietary Supplement	tetrahydrobiopterin (bh4)	1	2017
Behavioral	text message reminders	1	2017
Procedure	the cytokines modulations	1	2016
Device	the gpsâ„¢ ii platelet concentrate separation kit	1	2007
Device	the jarvik 2000 ventricular assist system	1	2007
Procedure	the kansas city cardiomyopathy questionnaire (kccq)	1	2006
Procedure	therapeutic thoracentesis	1	2008
Radiation	thoracic ct	1	2020
Procedure	thoracotomy	1	2014
Device	thoratec heartmate ii left ventricular assist system (lvas)	1	2005
Device	threshold imt	1	2019
Device	threshold inspiratory muscle trainer	1	2018
Device	thresholdâ® imt hs730, respironics inc, cedar grove, nj, usa	1	2015
Behavioral	time management	1	2017
Procedure	titration after the randomization phase	1	2011
Procedure	titration during the randomization phase	1	2011
Device	titration of nocturnal oxygen needs to prevent desaturations	1	2017
Dietary Supplement	to surgery patients, tocopherol capsules.	1	2008
Dietary Supplement	to surgery patients, tocotrienol capsules.	1	2008
Dietary Supplement	tocotrienol to healthy subjects.	1	2008
Drug	tolvaptan 30 mg	1	2016
Drug	tolvaptan 30 mg / iv diuretics	1	2016
Drug	tolvaptan tab 15 mg	1	2018
Drug	tolvaptan tablet 15mg	1	2017
Drug	tolvaptan/samsca	1	2012
Drug	tolvaptan/torasemide	1	2015
Behavioral	tomas	1	2018
Other	tomography positron emission	1	2015
Drug	tonapofylline	1	2008
Procedure	toning	1	2005
Behavioral	topic prompt list	1	2018
Drug	toprol-xl	1	2002
Drug	torasemide	1	2015
Drug	torasemide prolonged release	1	2006
Device	traditional biventricular pacing	1	2013
Drug	traditional chinese medicine	1	2013
Other	traditional icd programming	1	2013
Device	tragus stimulation	1	2016
Other	training	1	2013
Other	training of general practitioners in an uptitration protocol.	1	2010
Behavioral	training program intervention	1	2008
Drug	trandolapril	1	2006
Diagnostic Test	trans-thoracic echocardiography	1	2018
Procedure	trans-ventricular-septal placement of lv pacing lead	1	2013
Device	transcatheter atrial shunt system	1	2018
Device	transcatheter mitral valve repair	1	2018
Device	transcutaneous electrical stimulation	1	2018
Other	transesophageal echocardiography (tee)	1	2017
Other	transitional care intervention	1	2016
Behavioral	transitional care model	1	2014
Procedure	transmitral flow estimation	1	2016
Combination Product	transplant with hcv positive donor, followed by surveillance	1	2017
Combination Product	transplant with hcv positive donor, followed by surveillance/treatment of viremia	1	2017
Procedure	transthoracic echocardiogram (tte) assesment	1	2016
Diagnostic Test	transthoracic ecocardiogram	1	2019
Device	transthoracic impedance	1	2007
Device	transvenous left ventricular lead placement	1	2007
Procedure	transvenous placement of left ventricular lead	1	2011
Drug	treatment a	1	2019
Other	treatment as per model probability	1	2010
Other	treatment as per usual care	1	2010
Behavioral	treatment as usual	1	2014
Drug	treatment b	1	2019
Drug	treatment c	1	2019
Drug	treatment d	1	2019
Biological	treatment group	1	2007
Other	treatment in day-care heart failure unit	1	2017
Other	treatment of comorbidities	1	2015
Other	treatment of elderly patients in a gmw	1	2008
Other	treatment of elderly patients in ghhs	1	2008
Combination Product	treatment of viremia	1	2017
Drug	treatment with either metoprolol	1	2007
Drug	treatment with either metoprolol/carvedilol	1	2007
Device	triage bnp test	1	2005
Procedure	tricuspid valve repair	1	2018
Procedure	tricuspid valve repair (tvr)	1	2015
Procedure	tricuspid valve repair/replacement	1	2018
Device	triple-site biventricular pacing with peri-operative echo guidance	1	2015
Device	triple-site cardiac resynchronization	1	2008
Drug	trv027 dose #1	1	2013
Drug	trv027 dose #2	1	2013
Drug	trv027 dose #3	1	2013
Drug	tt-00920	1	2020
Device	tunneled pleural catheter	1	2018
Drug	two-hour dwell with 10% dextrose in sterile water	1	2018
Drug	two-hour dwell with dianeal low-calcium with 4.25% dextrose	1	2018
Behavioral	ufa dietary recommendations	1	2019
Drug	ularitide	1	2012
Other	ultra conservative icd programming	1	2013
Other	ultrafiltration using bvm	1	2009
Diagnostic Test	ultrasound evaluation of the inferior vena cava diameter	1	2017
Diagnostic Test	ultrasound examination	1	2018
Procedure	ultrasound examination by nurses	1	2013
Procedure	undersizing mitral annuloplasty	1	2017
Other	unfiltered diesel exhaust	1	2013
Other	untraining	1	2020
Drug	upfront therapy with oral spironolactone	1	2013
Procedure	upgrade to triple ventricular site crt	1	2009
Other	upper extremity aerobic exercise	1	2018
Other	upstream therapy	1	2009
Other	urine sample	1	2012
Drug	urocortin 2	1	2011
Drug	urocortin 2, urocortin 3	1	2012
Drug	urocortin 2, urocortin 3/substance p	1	2012
Drug	urocortin 3	1	2011
Drug	urotensine ii	1	2008
Behavioral	use of mobilemedminder	1	2012
Device	use of the c3-cloud it system	1	2019
Drug	usual care (standard-of-care) arm	1	2019
Device	usual care group	1	2007
Other	usual care iv diuretics	1	2017
Procedure	usual care of acute pulmonary oedema	1	2007
Behavioral	usual care program	1	2019
Behavioral	usual care treatment	1	2009
Behavioral	usual care with attention control	1	2016
Behavioral	usual care with educational material	1	2005
Behavioral	usual care/optimal discharge planning	1	2018
Behavioral	usual hf care	1	2015
Drug	usual long term cardiac medications	1	2005
Other	usual lvad care	1	2017
Drug	usual medications	1	2017
Other	usual outpatient care	1	2019
Other	usual treatment of patients with developing acute heart failure	1	2012
Device	v-lapâ„¢ system	1	2018
Device	v-wave interatrial shunt	1	2018
Device	vagus nerve stimulation (vns)	1	2013
Other	valsalva maneuver	1	2013
placebo	valsartan (lcz696) matching placebo	1	2015
Drug	valsartan 160 mg	1	2006
Drug	valsartan 160 mg bid	1	2006
Drug	valsartan oral tablet	1	2018
placebo	valsartan placebo	1	2016
Drug	valsartan/placebo	1	2017
Drug	valsartan/sacubitril/placebo	1	2017
Drug	valsatran	1	2017
Other	values inventory (vi)	1	2005
Drug	vasodilator	1	2017
Drug	vasopressin v2 receptor antagonist	1	2002
Biological	vaxigrip)	1	2009
Other	vehicle control	1	2009
Procedure	venous plethysmography	1	2014
Other	ventilation therapy	1	2010
Device	ventrassist left ventricular assist device	1	2007
Device	ventricular assist device system	1	2019
Device	ventricular) implantable defibrillator	1	2006
Other	verbal information	1	2016
Other	verbal information/discussion	1	2016
Drug	vericiguat	1	2016
Drug	vericiguat (bay1021189) 2.5 mg, 5 mg	1	2018
Drug	vericiguat (bay1021189) 2.5 mg, 5 mg/10 mg ir tablets	1	2018
Drug	verinurad	1	2020
Device	vfi	1	2019
Behavioral	viccy	1	2019
Drug	vildagliptin	1	2009
Behavioral	vipassana meditation practice	1	2008
Behavioral	vipassana meditation practice/instruction	1	2008
Device	visone ads	1	2018
Device	vitalpatch biosensor	1	2018
Dietary Supplement	vitamin b1	1	2009
Drug	vitamin c	1	2007
Dietary Supplement	vitamin c 1000 mg	1	2019
Dietary Supplement	vitamin c 500 mg	1	2019
Drug	vitamin d alone	1	2014
Drug	vitamin d/fish oil	1	2014
Drug	vitamin d3 (cholecalciferol)	1	2012
Device	vitaria system	1	2018
Device	vitatron biventricular pacemaker	1	2005
Device	vpd implant system	1	2007
Device	vr 9250	1	2010
Device	vr 9250 / dr 9550 / crt 9750	1	2010
Device	vv").	1	2015
Other	wait list	1	2008
Behavioral	walking exercise	1	2005
Other	walking/light weights	1	2014
Drug	warfarin / lmwh	1	2018
Drug	warfarin titrated to an inr of 2.5-3.0	1	2000
Behavioral	web-based training	1	2019
Behavioral	web-based training/telephone monitoring	1	2019
Other	web based telemonitoring system	1	2020
Other	website	1	2012
Other	website/interactive platform with telemonitoring.	1	2012
Procedure	weigh subjects on a scale in the standing position	1	2010
Behavioral	williams lifeskills	1	2017
Device	wise-crt	1	2018
Device	wise system	1	2016
Other	withdrawal of aspirin	1	2012
Drug	withdrawal of digoxin	1	2011
Other	withdrawal of oral medication (phosphodiesterase-5 inhibitor) in pretreated patients	1	2019
Drug	withdrawal of statin therapy	1	2012
Other	without autoset cs2	1	2007
Other	without codeine	1	2020
Device	without defibrillator	1	2005
Device	without implanted cardioverter defibrillator	1	2017
Radiation	x-rays in hospital	1	2010
Other	yã´ga	1	2017
Behavioral	yoga classes	1	2008
Behavioral	yoga program at home using internet technology	1	2014
Drug	zepatier	1	2017
Drug	zinc acetate	1	2008
Drug	zolpidem tartrate	1	2017

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	665
NA	120
France	69
United Kingdom	65
Canada	64
Germany	62
Brazil	49
Italy	48
Denmark	40
Spain	33
Japan	32
China	27
Netherlands	27
United States|Canada	26
Sweden	20
Israel	15
Australia	14
Belgium	14
Norway	14
Switzerland	14
Poland	13
Taiwan	12
Korea, Republic of	10
Austria	9
Russian Federation	7
Turkey	7
Egypt	6
Mexico	6
Finland	5
Greece	5
Iran, Islamic Republic of	5
United States|Germany	5
Colombia	4
India	4
Portugal	4
Argentina	3
Czechia	3
Hong Kong	3
Indonesia	3
Ireland	3
Singapore	3
Canada|Finland	2
Cyprus	2
Czechia|Poland	2
Germany|Poland	2
Kenya	2
Paraguay	2
Romania	2
Slovenia	2
Tunisia	2
United States|Australia|Canada|Germany|Greece|Italy|Norway|Poland|Portugal|Spain|Sweden	2
United States|Canada|United Kingdom	2
United States|New Zealand	2
United States|United Kingdom	2
Argentina|Brazil|Croatia|Georgia|Israel|Italy|Lebanon|Netherlands|Poland|Romania|Singapore|Spain|Sweden|Ukraine|United Kingdom	1
Argentina|Germany|Italy|Netherlands|Poland|Russian Federation	1
Armenia|Georgia|Moldova, Republic of	1
Australia|Austria|Belgium|Czechia|Denmark|France|Germany|Netherlands|New Zealand|Poland|United Kingdom	1
Australia|Austria|Canada|Czechia|Germany|Kazakhstan	1
Australia|Austria|Czech Republic|Denmark|Germany|Israel|Latvia	1
Australia|Austria|France|Germany|United Kingdom	1
Australia|Austria|Germany|Hungary|Netherlands|Poland|Russian Federation|United Kingdom	1
Australia|Belgium|Canada|Denmark|Germany|Netherlands|Turkey	1
Australia|Canada|Chile|Mexico|New Zealand	1
Australia|Czech Republic|Finland|France|Germany|Netherlands|Switzerland|United Kingdom	1
Australia|Czechia|Denmark	1
Australia|Czechia|France|Germany|Italy|Lithuania|Poland|Portugal|Spain|Sweden	1
Australia|Czechia|France|Germany|Netherlands|New Zealand|Poland|United Kingdom	1
Australia|Germany	1
Australia|Germany|Italy|Netherlands|New Zealand|Romania	1
Australia|Germany|Malaysia|New Zealand|United Kingdom	1
Australia|Hong Kong|Japan	1
Australia|Ireland|Netherlands|New Zealand|Sweden|United Kingdom	1
Austria|Bulgaria|Germany|Greece|Hungary|Israel|Italy|Poland|Portugal|Spain	1
Austria|Finland|Germany|India|Italy|Netherlands|Norway|Slovakia	1
Austria|France|Italy	1
Austria|Germany	1
Belarus|Belgium|Czechia|France|Italy|Lithuania|Netherlands|Poland|United Kingdom	1
Belgium|Bulgaria|Czech Republic|Denmark|Finland|France|Germany|Hungary|Ireland|Netherlands|Norway|Poland|Portugal|Romania|Russian Federation|Slovakia|South Africa|Spain|Sweden|Switzerland|United Kingdom	1
Belgium|Bulgaria|Czechia|Denmark|Estonia|Finland|France|Germany|Greece|Iceland|Ireland|Latvia|Lithuania|Netherlands|Norway|Poland|Spain|Sweden|United Kingdom	1
Belgium|Bulgaria|France|Hungary|Latvia|Netherlands|Poland|Serbia|Spain|United Kingdom	1
Belgium|Bulgaria|Hungary|Israel|Italy|Poland|Serbia|Spain|Switzerland	1
Belgium|Canada|Finland|France|Germany|India|Israel|Italy|Netherlands|Poland|Spain|Switzerland|United Kingdom	1
Belgium|Canada|France|Hungary|Italy|Netherlands|United Kingdom	1
Belgium|Croatia|Latvia	1
Belgium|Czechia|France|Germany|Italy|Netherlands|Spain|United Kingdom	1
Belgium|Denmark|Germany|Italy|Luxembourg|Netherlands|Norway	1
Belgium|France|Norway|Serbia	1
Belgium|Georgia	1
Belgium|Germany	1
Belgium|Germany|Ireland	1
Belgium|Germany|Italy|Slovakia|United Kingdom	1
Belgium|Germany|Poland|Romania	1
Belgium|Ireland	1
Belgium|Israel	1
Belgium|Israel|Poland|United Kingdom	1
Belgium|Italy	1
Belgium|Norway	1
Belgium|Serbia	1
Belgium|South Africa	1
Belgium|Taiwan	1
Belgium|United Kingdom	1
Belgium|United States|Australia|Austria|Bulgaria|Canada|China|Czech Republic|Denmark|France|Germany|Greece|Hungary|Israel|Italy|Japan|Korea, Republic of|Netherlands|Poland|Portugal|Singapore|Spain|Sweden|Switzerland|Taiwan|United Kingdom	1
Brazil|Bulgaria|Germany|Spain|Switzerland	1
Brazil|Canada|Sweden|Taiwan	1
Brazil|Greece|Poland|Spain|United States|Argentina|Australia|Bulgaria|Canada|China|Czechia|Denmark|Estonia|France|Germany|Hungary|Japan|Korea, Republic of|Latvia|Lithuania|Malaysia|Mexico|Netherlands|Portugal|Romania|Russian Federation|Slovakia|South Africa|Sweden|Turkey|Ukraine|United Kingdom	1
Bulgaria	1
Cameroon	1
Cameroon|China|India|Kenya|Lebanon|Mozambique|Nigeria|Philippines|Saudi Arabia|Sudan|Uganda|United Arab Emirates|Zambia	1
Canada|France|Germany|Italy	1
Canada|Malaysia|Sweden	1
China|Hong Kong|Japan|Korea, Republic of	1
Croatia|Czechia|Israel|Latvia|United States|Argentina|Australia|Austria|Belarus|Bosnia and Herzegovina|Brazil|Bulgaria|Canada|Colombia|Denmark|Estonia|Georgia|Germany|Greece|Hungary|Lithuania|Mexico|Netherlands|North Macedonia|Peru|Poland|Portugal|Puerto Rico|Romania|Russian Federation|Serbia|Slovakia|South Africa|Spain|Turkey|Ukraine|United Kingdom	1
Czech Republic|Denmark|Estonia|Germany|Greece|Guatemala|India|Italy|Latvia|Lithuania|Poland|Romania|Russian Federation|Singapore|Slovakia	1
Czech Republic|France|Italy|Netherlands|Serbia|Slovakia|United Kingdom	1
Czechia|Denmark|Kazakhstan	1
Czechia|Georgia	1
Denmark|Germany|Italy|Netherlands|Switzerland	1
Denmark|Norway|United Kingdom	1
El Salvador|Guatemala	1
Estonia|Slovenia|Spain|Sweden|United Kingdom	1
Estonia|United States|Argentina|Australia|Austria|Belgium|Brazil|Canada|China|Colombia|Costa Rica|Czech Republic|Denmark|Dominican Republic|Finland|France|Germany|Greece|India|Ireland|Italy|Japan|Korea, Republic of|Latvia|Lithuania|Mexico|Netherlands|Norway|Peru|Poland|Portugal|Puerto Rico|Romania|Russian Federation|Slovakia|South Africa|Spain|Sweden|Switzerland|Taiwan|Thailand|Turkey|United Kingdom|Venezuela	1
France|Argentina|Austria|Colombia|Hungary|Israel|Mozambique|Nigeria|Russian Federation|Slovakia|South Africa|Tunisia	1
France|Argentina|Belgium|Canada|Czechia|Germany|Italy|Lebanon|Norway|Poland|Portugal|Russian Federation|Saudi Arabia|Slovakia|Spain|Sweden|Switzerland|Turkey|United Kingdom	1
France|Australia|Czechia|Denmark|Finland|Germany|Netherlands|Norway|Sweden|Switzerland|United Kingdom	1
France|Germany|Ireland|Italy|Netherlands|United Kingdom	1
France|Germany|Italy|Netherlands|Portugal|Spain	1
France|Germany|Italy|Netherlands|Spain|United Kingdom	1
France|Italy|Portugal|Spain	1
France|Martinique	1
France|Sweden	1
France|United States|Argentina|Australia|Austria|Belgium|Brazil|Bulgaria|Canada|Chile|Colombia|Czechia|Denmark|Germany|Greece|Hungary|Ireland|Israel|Italy|Mexico|Netherlands|Norway|Peru|Poland|Portugal|Puerto Rico|Romania|Russian Federation|Slovakia|South Africa|Spain|Sweden|Switzerland|Turkey|United Kingdom	1
France|United States|Bulgaria|Czechia|Georgia|Hungary|Poland|Russian Federation|Spain|Ukraine|United Kingdom	1
Georgia	1
Georgia|Slovenia	1
Georgia|Ukraine	1
Germany|Austria|Belgium|Czech Republic|Denmark|Finland|Israel|Norway|Poland|Sweden	1
Germany|Hungary|Italy|Poland|Portugal|Serbia|Slovenia|Spain	1
Germany|Hungary|Spain	1
Germany|India|Peru	1
Germany|Israel|Spain	1
Germany|Italy	1
Germany|Italy|Netherlands|Poland	1
Germany|Italy|Netherlands|Serbia	1
Germany|Italy|United States|Argentina|Belgium|Brazil|Canada|Czech Republic|France|Netherlands|Norway|Poland|Romania|Russian Federation|Spain|Sweden|Switzerland|United Kingdom	1
Germany|Lithuania	1
Germany|Poland|Russian Federation	1
Germany|Serbia	1
Germany|Spain|Switzerland	1
Germany|Sweden	1
Germany|Switzerland	1
Germany|United States|Argentina|Austria|Belgium|Brazil|Bulgaria|Canada|Colombia|Czechia|Denmark|Estonia|France|Guatemala|Hungary|India|Israel|Italy|Latvia|Lithuania|Mexico|Netherlands|Peru|Portugal|Puerto Rico|Romania|Russian Federation|Serbia|Slovakia|Spain|Thailand|Turkey|United Kingdom	1
Greece|Italy|Argentina|Germany|Norway|Poland|Romania|Russian Federation|Spain|Ukraine	1
Greece|Poland	1
Hungary|Poland	1
Hungary|United States|Argentina|Belgium|Brazil|Canada|Colombia|Czech Republic|Finland|France|Germany|India|Israel|Italy|Philippines|Poland|Romania|Russian Federation|Singapore|Slovakia|Spain|Sweden|Taiwan|Turkey	1
Ireland|Netherlands	1
Israel|Germany|Hungary|United States|Belgium|Denmark|Netherlands|Poland|Sweden|United Kingdom	1
Italy|Latvia|United States|Argentina|Belgium|Brazil|Canada|Czechia|Estonia|Finland|France|Germany|Hungary|Israel|Lithuania|Netherlands|Poland|Romania|Serbia|Spain|Switzerland|Turkey	1
Italy|Netherlands|United Kingdom	1
Italy|Switzerland	1
Italy|United Kingdom	1
Japan|United States|Brazil|Canada|Denmark|Korea, Republic of|Slovakia|South Africa|Sweden	1
Kazakhstan	1
Malta|Belgium|Croatia|Cyprus|Denmark|Estonia|France|Hungary|Israel|Italy|Latvia|Lithuania|Norway|Poland|Portugal|Russian Federation|Slovenia|Spain	1
Mozambique|Philippines|Uganda	1
Netherlands|United Kingdom	1
Panama	1
Poland|Russian Federation	1
Poland|Russian Federation|Slovenia	1
Poland|Slovakia|Spain|Sweden|United Kingdom	1
Poland|United States|Australia|Austria|Bulgaria|Canada|Czech Republic|Denmark|Finland|France|Germany|Greece|Hungary|Israel|Italy|Korea, Republic of|Lithuania|Netherlands|Norway|Portugal|South Africa|Spain|Sweden|Taiwan|Turkey	1
Serbia	1
Serbia|United States|Australia|Austria|Belgium|Canada|Denmark|Germany|Greece|Hong Kong|Hungary|Italy|Japan|Netherlands|Norway|Russian Federation|Saudi Arabia|Spain|Sweden	1
Spain|Sweden|United Kingdom	1
Spain|Switzerland|Japan|Netherlands|Norway|United States|Austria|Denmark|Germany|Greece|Italy|United Kingdom	1
Sweden|United States	1
United States|Argentina|Australia|Austria|Belgium|Brazil|Bulgaria|Canada|Chile|China|Colombia|Czechia|Denmark|France|Germany|Greece|Hungary|Italy|Japan|Lithuania|Mexico|Netherlands|New Zealand|Poland|Portugal|Puerto Rico|Romania|Russian Federation|Slovakia|South Africa|Spain|Sweden|Switzerland|Turkey|Ukraine|United Kingdom	1
United States|Argentina|Australia|Austria|Belgium|Brazil|Bulgaria|Canada|Chile|Czechia|Denmark|Estonia|Finland|France|Germany|Hong Kong|Hungary|India|Israel|Italy|Latvia|Lithuania|Mexico|Netherlands|Norway|Poland|Portugal|Puerto Rico|Romania|Russian Federation|Slovakia|South Africa|Spain|Sweden|Switzerland|United Kingdom	1
United States|Argentina|Australia|Austria|Belgium|Brazil|Canada|Chile|Czechia|Denmark|Finland|France|Germany|Greece|Hungary|Israel|Italy|Korea, Republic of|Latvia|Lithuania|Netherlands|New Zealand|Poland|Portugal|Romania|Russian Federation|Slovakia|Spain|Sweden|Switzerland|Turkey|United Kingdom	1
United States|Argentina|Australia|Austria|Bulgaria|Canada|Germany|Korea, Republic of|Russian Federation|Slovakia	1
United States|Argentina|Australia|Belgium|Brazil|Canada|China|Colombia|Czechia|Germany|Hungary|India|Italy|Japan|Korea, Republic of|Mexico|Netherlands|Poland|Romania|Singapore|South Africa|Spain|United Kingdom	1
United States|Argentina|Australia|Belgium|Brazil|Canada|China|Czechia|France|Germany|Hungary|India|Italy|Japan|Korea, Republic of|Mexico|Netherlands|Poland|Spain|United Kingdom	1
United States|Argentina|Australia|Belgium|Brazil|Canada|Czech Republic|Denmark|France|Germany|Greece|Hungary|Ireland|Italy|Mexico|Netherlands|Norway|Poland|Portugal|Russian Federation|South Africa|Spain|Sweden|Switzerland|United Kingdom	1
United States|Argentina|Australia|Belgium|Bulgaria|Canada|Croatia|France|Germany|Italy|Korea, Republic of|Lithuania|Netherlands|Poland|Russian Federation|Spain|Switzerland|Taiwan|Turkey|United Kingdom	1
United States|Argentina|Australia|Belgium|Canada|Chile|Denmark|Greece|Hungary|Israel|Poland|Portugal|Romania|South Africa|Sweden	1
United States|Argentina|Australia|Belgium|Canada|Czechia|France|Germany|Greece|Hong Kong|Hungary|India|Ireland|Italy|Korea, Republic of|Mexico|Netherlands|Poland|Portugal|Russian Federation|Singapore|Slovakia|South Africa|Spain|Sweden|Ukraine|United Arab Emirates|United Kingdom|Venezuela	1
United States|Argentina|Australia|Brazil|Bulgaria|Canada|Chile|China|Colombia|France|Germany|Greece|India|Israel|Korea, Republic of|Lithuania|Malaysia|Mexico|Netherlands|New Zealand|Norway|Poland|Russian Federation|Singapore|Sweden|Taiwan|Thailand|Ukraine	1
United States|Argentina|Australia|Brazil|Bulgaria|Canada|Czech Republic|Finland|France|Germany|India|Israel|Italy|Netherlands|Poland|Romania|Russian Federation|Sweden	1
United States|Argentina|Austria|Belgium|Bulgaria|Canada|Colombia|Germany|Greece|Hungary|Israel|Italy|Japan|Malaysia|Poland|Portugal|Russian Federation|Singapore|South Africa|Spain|Taiwan	1
United States|Argentina|Austria|Brazil|Bulgaria|Czechia|Denmark|France|Germany|Hungary|Israel|Poland|Romania|Russian Federation|Spain|Sweden|United Kingdom	1
United States|Argentina|Austria|Bulgaria|Canada|China|Croatia|Czechia|Finland|France|Germany|Hungary|India|Israel|Italy|Japan|Jordan|Korea, Republic of|Lebanon|Poland|Portugal|Puerto Rico|Romania|Russian Federation|Saudi Arabia|Singapore|South Africa|Spain|Sweden|Switzerland|Taiwan|Thailand|Turkey	1
United States|Argentina|Austria|Bulgaria|Denmark|France|Germany|Hungary|Israel|Poland|Romania|Russian Federation|Sweden|United Kingdom	1
United States|Argentina|Belgium|Brazil|Bulgaria|Canada|Chile|Czechia|Denmark|Estonia|Finland|France|Germany|Guatemala|Hong Kong|Hungary|India|Israel|Italy|Korea, Republic of|Latvia|Lithuania|Malaysia|Mexico|Netherlands|Panama|Peru|Philippines|Poland|Portugal|Romania|Russian Federation|Singapore|Slovakia|South Africa|Spain|Sweden|Taiwan|Thailand|Turkey|United Kingdom	1
United States|Argentina|Belgium|Brazil|Bulgaria|Canada|China|Czechia|France|Hungary|Japan|Mexico|Netherlands|Peru|Poland|Romania|Russian Federation|Saudi Arabia|Spain|Taiwan|Vietnam	1
United States|Argentina|Brazil|Bulgaria|Canada|China|Czechia|Denmark|Germany|Hungary|India|Japan|Netherlands|Poland|Russian Federation|Slovakia|Sweden|Taiwan|United Kingdom|Vietnam	1
United States|Argentina|Brazil|Bulgaria|Canada|Denmark|Italy|Japan|Korea, Republic of|Slovakia|South Africa|Sweden	1
United States|Argentina|Brazil|Canada|Finland	1
United States|Argentina|Brazil|Canada|Georgia|Russian Federation	1
United States|Argentina|Brazil|Canada|Germany|India|Italy|Netherlands|Poland|Romania|Russian Federation|Singapore|Spain|Venezuela	1
United States|Argentina|Bulgaria|Canada|Czechia|Germany|Hungary|Israel|Poland|Romania|Russian Federation|Slovakia	1
United States|Argentina|Canada|Czechia|France|Germany|Greece|Italy|Japan|Netherlands|Poland|Spain|United Kingdom	1
United States|Australia|Austria|Belgium|Bulgaria|Canada|China|Czech Republic|Denmark|France|Germany|Greece|Hungary|Israel|Italy|Japan|Korea, Republic of|Netherlands|Poland|Singapore|Spain|Sweden|Switzerland|Taiwan|United Kingdom	1
United States|Australia|Austria|Belgium|Canada|Chile|Denmark|Finland|France|Germany|Greece|Hungary|India|Israel|Italy|Malaysia|Netherlands|Norway|Romania|Saudi Arabia|Serbia|Slovakia|Slovenia|South Africa|Spain|Switzerland|United Kingdom	1
United States|Australia|Austria|Belgium|Canada|China|Colombia|Denmark|Finland|France|Germany|Greece|India|Israel|Italy|Korea, Republic of|Lebanon|Malaysia|Malta|Netherlands|Poland|Portugal|Puerto Rico|Saudi Arabia|Singapore|South Africa|Spain|Sweden|Switzerland|Taiwan|United Kingdom	1
United States|Australia|Austria|Belgium|Canada|Croatia|Denmark|France|Germany|Italy|Japan|Netherlands|Poland|Spain|United Kingdom	1
United States|Australia|Austria|Canada|Denmark|France|Italy|Saudi Arabia	1
United States|Australia|Austria|France|Germany|Italy|Netherlands|Portugal|Slovenia|Spain|Switzerland|United Kingdom	1
United States|Australia|Belgium|Bulgaria|Canada|Czech Republic|Finland|France|Germany|Greece|Hungary|Italy|Lithuania|Netherlands|Norway|Poland|Russian Federation|Slovakia|United Kingdom	1
United States|Australia|Belgium|Bulgaria|Canada|Czechia|Germany|Hungary|Italy|Lithuania|Netherlands|Poland|United Kingdom	1
United States|Australia|Belgium|Canada|France|Germany|Israel|Poland|Spain	1
United States|Australia|Belgium|Netherlands|United Kingdom	1
United States|Australia|Canada|Israel	1
United States|Australia|Canada|New Zealand	1
United States|Australia|Canada|New Zealand|Poland	1
United States|Australia|Czech Republic|Finland|Germany|Italy|Netherlands|Norway|Romania|Russian Federation|Spain|Sweden|Turkey	1
United States|Australia|Czechia	1
United States|Australia|Czechia|Germany|Hungary|Italy|Norway|United Kingdom	1
United States|Australia|Denmark|France|Germany|Italy|Netherlands|United Kingdom	1
United States|Australia|New Zealand	1
United States|Austria|Belgium|Bulgaria|Germany|Greece|Israel|Italy|Japan|Poland|Portugal|Spain	1
United States|Austria|Belgium|Canada|Czech Republic|Denmark|France|Germany|Hungary|Ireland|Italy|Norway|Spain|Sweden|United Kingdom	1
United States|Austria|Denmark|France|Germany|Greece|Israel|Poland|Switzerland|United Kingdom	1
United States|Belgium|Argentina|Australia|Austria|Brazil|Bulgaria|Canada|China|Colombia|Croatia|Czechia|Denmark|Finland|France|Germany|Greece|Guatemala|Hungary|India|Israel|Italy|Japan|Korea, Republic of|Mexico|Netherlands|Norway|Peru|Philippines|Poland|Romania|Russian Federation|Serbia|Singapore|Slovakia|Slovenia|South Africa|Spain|Sweden|Switzerland|Taiwan|Turkey|United Kingdom	1
United States|Belgium|Bulgaria|Germany|Greece|Israel|Italy|Japan|Netherlands|Poland|Spain	1
United States|Belgium|Canada|Germany|Israel|Netherlands|Poland|Spain|Switzerland	1
United States|Belgium|Canada|Italy|Netherlands	1
United States|Belgium|Germany|Netherlands|Singapore	1
United States|Brazil|Canada|France|Germany|Italy|Japan|Spain|United Kingdom	1
United States|Bulgaria|Canada|Chile|Hungary|Korea, Republic of|Romania|Russian Federation|Thailand|Ukraine	1
United States|Bulgaria|Canada|Croatia|Czechia|Israel|Italy|Japan|Korea, Republic of|Lebanon|Poland|Portugal|Singapore|South Africa|Switzerland|Taiwan|Thailand|Turkey	1
United States|Bulgaria|Finland|Germany|Hungary|Italy|Puerto Rico|Slovakia|Spain|Turkey|United Kingdom	1
United States|Canada|China	1
United States|Canada|Czech Republic|Germany|Italy|Netherlands|South Africa|Sweden	1
United States|Canada|France	1
United States|Canada|France|Germany|Ireland|Italy|Japan|Netherlands|Spain|Switzerland|United Kingdom	1
United States|Canada|France|Germany|Italy|Netherlands|Spain|Switzerland|United Kingdom	1
United States|Canada|Germany|Hong Kong|Italy|Malaysia|Netherlands|Norway|Spain|Sweden	1
United States|Canada|Hong Kong|United Kingdom	1
United States|Canada|Hungary|Netherlands|Poland|Serbia	1
United States|Canada|Italy	1
United States|Canada|Italy|Netherlands	1
United States|Canada|Netherlands	1
United States|Canada|New Zealand	1
United States|Canada|Puerto Rico	1
United States|Czech Republic|Georgia|Germany|Poland|Russian Federation|Ukraine	1
United States|Czechia|Germany	1
United States|Czechia|Poland	1
United States|Denmark|Germany|Netherlands|Norway|Spain	1
United States|Finland|Germany|Netherlands|Sweden	1
United States|France|Germany	1
United States|France|Germany|Netherlands|Poland|Sweden|United Kingdom	1
United States|France|Greece|Poland|United Kingdom	1
United States|France|Italy|United Kingdom	1
United States|Georgia|Russian Federation|United Kingdom	1
United States|Germany|Israel	1
United States|Germany|Israel|Italy|Netherlands|Sweden	1
United States|Germany|Italy	1
United States|Germany|Jordan|Poland|Russian Federation	1
United States|Germany|Netherlands|Poland	1
United States|Germany|United Kingdom	1
United States|India	1
United States|Israel	1
United States|Israel|Mexico|Romania|Russian Federation|Ukraine	1
United States|Japan|Netherlands|United Kingdom	1
United States|Paraguay	1
United States|Romania	1
United States|Serbia	1
United States|Switzerland	1

Sites per Study

Site_count	Study_Count
1	1159
2	130
3	58
4	40
5	23
6	20
7	15
8	10
9	14
10	18
11	11
12	8
13	11
14	6
15	12
16	10
17	9
18	8
19	5
20	5
21	4
22	8
23	5
24	8
25	6
26	5
27	1
28	3
29	1
30	2
31	4
32	4
33	5
34	4
35	5
36	4
37	4
38	2
39	2
40	3
42	3
44	2
45	3
46	1
47	5
48	2
49	1
50	2
51	2
52	3
53	3
54	4
55	1
56	1
58	1
59	2
62	1
64	3
65	2
66	1
67	1
69	2
71	1
72	1
73	1
75	2
76	2
77	1
78	1
79	1
80	1
81	3
82	1
83	1
86	2
90	2
94	2
95	1
97	1
99	1
101	1
102	1
105	2
108	3
109	1
113	1
116	1
118	1
121	1
124	1
125	1
127	1
134	1
137	1
139	1
150	1
154	1
159	1
163	1
166	1
177	1
189	1
190	1
203	1
204	1
213	1
218	1
226	1
231	1
235	1
239	1
267	1
270	1
308	2
331	1
337	1
378	2
397	1
398	1
414	1
417	1
466	1
518	1
542	1
578	1
617	2
754	1
808	2
1034	1

Phase

Phase	Study_Count
N/A	915
Phase 2	237
Phase 4	220
Phase 3	203
Phase 1	86
Phase 1/Phase 2	49
Phase 2/Phase 3	49
Early Phase 1	20

Number of Arms

Number_of_Arms	Count_of_Studies
1	358
2	1028
3	138
4	61
5	15
6	15
7	3
8	2
10	1
NA	158

Number of Updates

Count of Versions	Count of Studies
1	188
2	241
3	226
4	215
5	164
6	142
7	104
8	80
9	65
10	53
11	46
12	37
13	27
14	30
15	10
16	15
17	13
18	15
19	9
20	11
21	7
22	7
23	6
24	8
25	2
26	4
27	3
28	2
29	3
30	5
31	1
32	3
33	3
34	1
35	1
36	3
37	1
39	3
41	2
42	3
46	2
47	1
48	1
49	1
51	1
52	2
55	1
58	2
66	1
67	1
68	1
71	1
80	1
82	1
88	1
90	1
249	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	10812	1591	6.795726
Contacts/Locations	5870	1358	4.322533
Recruitment Status	2430	1378	1.763425
Study Design	1853	1170	1.583761
None (earliest Version on record)	1779	1779	1.000000
Outcome Measures	1384	780	1.774359
Eligibility	1147	681	1.684288
Sponsor/Collaborators	1112	725	1.533793
Arms	1078	711	1.516174
Interventions	1078	711	1.516174
Study Description	1006	612	1.643791
Study Identification	946	602	1.571429
Oversight	751	606	1.239274
References	468	278	1.683453
Conditions	332	244	1.360656
Results	277	277	1.000000
More Information	234	142	1.647887
IPDSharing	193	173	1.115607
Results Submission Events	111	111	1.000000
Documents	84	76	1.105263
Baseline Characteristics	67	59	1.135593
Reported Adverse Events	46	43	1.069767
Participant Flow	37	35	1.057143
2020Recruitment Status	2	2	1.000000
2020 Outcome Measures	1	1	1.000000
2020 Study Status	1	1	1.000000
Quality Control Review has not concludedReturned: February 7	1	1	1.000000
Quality Control Review has not concludedReturned: January 31	1	1	1.000000
Quality Control Review has not concludedReturned: March 30	1	1	1.000000
Quality Control Review has not concludedReturned: May 28	1	1	1.000000

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	5.0	1.000	4.00000	4.000	1.0000	5.0000	1.000	4.0000
1st Qu.	13.0	30.000	12.00000	24.500	30.5000	48.5000	80.000	40.0000
Median	20.5	79.000	25.00000	36.500	69.0000	101.0000	267.000	80.0000
Mean	50.5	563.102	36.77647	67.625	136.6426	229.7708	1330.096	558.0323
3rd Qu.	42.5	209.500	49.00000	60.000	160.0000	276.0000	1009.000	304.0000
Max.	300.0	197692.000	150.00000	1000.000	2135.0000	2200.0000	25875.000	50000.0000

Trial Group Type

group_type	Group_Count
Experimental	1571
Active Comparator	782
Placebo Comparator	386
No Intervention	292
Other	219
NA	158
Sham Comparator	34

Intervention Model

intervention_model	Study_Count
Parallel Assignment	1143
Single Group Assignment	429
Crossover Assignment	137
Factorial Assignment	32
Sequential Assignment	21
NA	17

Primary Purpose

primary_purpose	Study_Count
Treatment	1176
Supportive Care	140
Diagnostic	114
Prevention	89
Health Services Research	71
Other	62
NA	56
Basic Science	51
Device Feasibility	10
Screening	8
Educational/Counseling/Training	2

Observational Studies

Studies by Country

Country	Study_Count
United States	213
NA	66
Germany	49
France	30
Italy	26
United Kingdom	24
Canada	15
China	14
Israel	14
Spain	11
Netherlands	10
Australia	7
Denmark	6
Korea, Republic of	6
Sweden	6
Poland	5
Switzerland	5
Taiwan	5
Turkey	5
Greece	4
Japan	4
Austria	3
Brazil	3
Singapore	3
Belgium	2
Croatia	2
Egypt	2
Finland	2
Indonesia	2
Norway	2
Russian Federation	2
Tunisia	2
United States|Canada	2
United States|Canada|Germany	2
United States|Israel	2
Australia|Austria|Canada|Czechia|Germany|Kazakhstan	1
Australia|Belgium|Denmark|France|United Kingdom	1
Austria|Belgium|Canada|France|Italy|United States|Netherlands|Spain	1
Austria|Belgium|Denmark|Germany|Hong Kong	1
Austria|Czech Republic|France|Germany|Israel|Italy|Latvia|Netherlands|Spain|United Kingdom	1
Austria|Denmark|Finland|Germany|Italy|Latvia|Netherlands|Singapore|Spain|Switzerland|United Kingdom	1
Austria|Germany|Hungary	1
Austria|Hungary|North Macedonia|Poland|Serbia|Spain	1
Bangladesh	1
Belgium|France	1
Belgium|Spain|Switzerland	1
China|Hong Kong|India|Indonesia|Japan|Korea, Republic of|Malaysia|Philippines|Singapore|Thailand	1
Czechia	1
Denmark|France|Germany	1
Denmark|France|Germany|Netherlands|Sweden|United Kingdom	1
Former Serbia and Montenegro|Belgium|India|Kuwait|Russian Federation|Saudi Arabia	1
France|Germany	1
France|Lithuania	1
France|Sweden	1
Germany|Switzerland	1
Hungary	1
India	1
Italy|Spain	1
Oman	1
Pakistan	1
Romania	1
Slovenia	1
Thailand	1
United States|Argentina|Colombia|Japan	1
United States|Australia	1
United States|Australia|Belgium|Canada|Denmark|France|Germany|Hong Kong|Ireland|Italy|Netherlands|Spain|United Kingdom	1
United States|Austria|Belgium|Denmark|Finland|France|Germany|Hong Kong|Italy|Netherlands|Norway|Spain|United Kingdom	1
United States|Austria|France|Germany	1
United States|Austria|Germany	1
United States|Belgium|Canada|France|Germany|Italy|Netherlands|Sweden|Switzerland|United Kingdom	1
United States|Belgium|Canada|France|Germany|Netherlands|Switzerland|United Kingdom	1
United States|Belgium|Canada|Germany|Japan|Poland|Portugal	1
United States|Belgium|Greece|Italy|Switzerland|United Kingdom	1
United States|Bulgaria|Canada|Czech Republic|France|Germany|Italy|Russian Federation|Sweden	1
United States|Canada|China|France|Germany|Hong Kong|India|Malaysia|Malta|Pakistan|Poland|Puerto Rico|Romania|Singapore|Taiwan|Thailand	1
United States|Canada|Israel|Singapore|United Kingdom	1
United States|Canada|United Kingdom	1
United States|Croatia	1
United States|Czech Republic|Germany|Hong Kong|Hungary|Israel|Italy|Malaysia|Netherlands|Slovakia|Thailand|United Kingdom	1
United States|Germany|Greece|Italy|New Zealand|Poland|Switzerland|United Kingdom	1
United States|Germany|Hong Kong|Italy|Poland	1
United States|Greece|Ireland|Italy|Netherlands|Spain|Switzerland	1
United States|India|Sweden	1
United States|Italy	1
United States|Netherlands|Switzerland	1

Sites per Study

Site_count	Study_Count
1	422
2	44
3	19
4	17
5	13
6	7
7	8
8	5
9	1
10	4
11	2
12	3
13	4
14	2
15	4
16	2
17	1
18	1
19	4
20	1
21	1
23	1
24	2
25	2
27	1
28	1
29	1
32	2
33	1
34	2
41	1
45	1
51	1
52	3
60	3
64	1
67	1
71	1
77	1
82	2
86	1
88	1
93	1
99	2
103	1
105	1
108	1
112	1
128	1
129	1
144	1
343	1

Number of Updates

Count of Versions	Count of Studies
1	80
2	117
3	96
4	80
5	64
6	39
7	24
8	31
9	19
10	11
11	7
12	7
13	9
14	6
15	2
17	3
19	2
20	1
26	1
27	2
32	1
33	1
51	1
58	1
83	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	2389	526	4.541825
Contacts/Locations	946	409	2.312958
Recruitment Status	685	436	1.571101
None (earliest Version on record)	606	606	1.000000
Study Design	540	375	1.440000
Sponsor/Collaborators	311	214	1.453271
Eligibility	249	172	1.447674
Study Description	242	160	1.512500
Study Identification	218	157	1.388535
Outcome Measures	191	149	1.281879
Groups	157	116	1.353448
Interventions	157	116	1.353448
Oversight	137	119	1.151261
References	108	61	1.770492
Conditions	80	58	1.379310
IPDSharing	58	57	1.017544
Results	30	30	1.000000
More Information	18	14	1.285714
Results Submission Events	16	16	1.000000
Documents	10	9	1.111111
Baseline Characteristics	4	4	1.000000
Participant Flow	2	2	1.000000
Reported Adverse Events	2	2	1.000000

Enrollment Metrics

Measure	Observational
Min	1.00
1st Qu	60.00
Median	180.00
Mean	14746.72
3rd Qu	581.25
Max	2240000.00

Observation Model

observational_model	Study_Count
Cohort	356
Case-Only	81
NA	49
Other	40
Case-Control	37
Case Control	30
Case-Crossover	5
Defined Population	3
Ecologic or Community	3
Defined Population, Natural History	2

Time Perspective

time_perspective	Study_Count
Prospective	461
Retrospective	72
Cross-Sectional	33
NA	24
Other	11
Longitudinal, Prospective	3
Cross-Sectional, Prospective	1
Longitudinal, Retrospective	1

Registries

Studies by Country

Country	Study_Count
United States	15
Germany	13
Italy	8
Israel	5
NA	5
Canada	4
China	4
France	4
Poland	3
Japan	2
Korea, Republic of	2
Netherlands	2
Russian Federation	2
Singapore	2
Spain	2
Switzerland	2
Tunisia	2
United Kingdom	2
Australia|Austria|Belgium|Denmark|Finland|Germany|Italy|Kazakhstan|Lebanon|Netherlands|Norway|Poland|Serbia|Spain|Switzerland|Turkey|United Kingdom	1
Australia|Germany	1
Austria	1
Austria|Australia|Belgium|Czechia|France|Germany|Hungary|Israel|Latvia|Poland|Portugal|Singapore|Slovakia|South Africa|Spain|Switzerland|Taiwan|United Kingdom	1
Austria|Belgium|Colombia|Denmark|Finland|France|Germany|Hong Kong|Ireland|Israel|Italy|Japan|Netherlands|Portugal|Singapore|Spain|Switzerland|United Kingdom	1
Colombia	1
Germany|Hungary|Italy|Kazakhstan|Netherlands|Turkey|United Kingdom	1
Germany|Italy	1
Germany|Italy|Poland|Russian Federation|Slovenia|United Kingdom	1
Germany|Sweden|Switzerland	1
Hungary	1
Kuwait	1
Mexico	1
Sweden	1
Turkey	1
Uganda	1
United States|Argentina|Brazil|China|Colombia|India|Japan|Korea, Republic of|Puerto Rico	1
United States|Australia|Austria|Belgium|Canada|Czechia|France|Germany|Italy|Netherlands|Portugal|Slovakia|Spain|Switzerland|United Kingdom	1
United States|Australia|Austria|Belgium|Canada|Denmark|Former Serbia and Montenegro|France|Germany|Italy|Netherlands|Spain|Sweden|Switzerland	1
United States|Austria|Germany|Poland	1
United States|Belgium|Canada|France|Germany|Hungary|Italy|Korea, Republic of|Malaysia|Netherlands|Slovakia|Spain|United Kingdom	1
United States|Belgium|Canada|France|Germany|Italy|Korea, Republic of|Malaysia|Netherlands|Serbia|Spain|Sweden|Switzerland|United Kingdom	1
United States|France|Germany|Italy|Korea, Republic of|Malaysia|Spain|Sweden|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	71
2	2
5	3
6	1
8	1
9	1
11	2
12	1
13	1
16	1
17	1
19	1
21	1
22	1
31	1
32	1
33	1
34	1
48	1
69	1
77	1
79	1
83	1
106	1
123	1
130	1
139	1
199	1

Number of Updates

Count of Versions	Count of Studies
1	19
2	16
3	17
4	11
5	15
6	4
7	7
8	1
10	2
11	2
12	1
13	2
14	1
20	1
26	1
28	1
54	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	418	83	5.036145
Contacts/Locations	235	62	3.790323
None (earliest Version on record)	102	102	1.000000
Recruitment Status	84	54	1.555556
Study Design	53	39	1.358974
Study Description	47	22	2.136364
Outcome Measures	44	29	1.517241
Eligibility	31	19	1.631579
Sponsor/Collaborators	25	19	1.315789
Oversight	24	19	1.263158
Study Identification	20	16	1.250000
Groups	13	10	1.300000
Interventions	13	10	1.300000
Conditions	12	10	1.200000
References	12	10	1.200000
IPDSharing	9	8	1.125000
Results	4	4	1.000000
Results Submission Events	4	4	1.000000
Documents	3	3	1.000000

Enrollment Metrics

Measure	Registries
Min	10.0
1st Qu	200.0
Median	610.0
Mean	107147.9
3rd Qu	2030.0
Max	7205000.0

Registry Model

observational_model	Study_Count
Cohort	81
Case-Only	10
Other	5
Case-Control	4
Case-Crossover	1
NA	1

Time Perspective

time_perspective	Study_Count
Prospective	91
Other	6
Cross-Sectional	4
Retrospective	1

Follow-up

target_duration	Study_Count
12 Months	14
1 Year	12
5 Years	11
3 Years	10
2 Years	9
1 Day	8
10 Years	6
6 Months	5
3 Months	3
1 Month	2
18 Months	2
24 Months	2
4 Weeks	2
5 Days	2
8 Years	2
1 Week	1
12 Years	1
15 Years	1
3 Days	1
30 Days	1
30 Months	1
376 Days	1
4 Months	1
4 Years	1
50 Years	1
6 Years	1
7 Months	1